TWO NEW ISOINDOLIN-1-ONES FROM THE LEAVES OF NICOTIANA TABACUM AND THEIR ANTI-TOBACCO MOSAIC VIRUS ACTIVITIES

被引：30

作者：

Kong, Guang-Hui ^{[1
]}

Wu, Yu-Ping ^{[1
,2
]}

Li, Wei ^{[1
]}

Xia, Zhen-Yuan ^{[1
]}

Liu, Qiang ^{[2
]}

Wang, Kun-Miao ^{[2
]}

He, Pei ^{[2
]}

Zhu, Rui-Zhi ^{[2
]}

Si, Xiao-Xi ^{[2
]}

Yang, Guang-Yu ^{[2
]}

机构：

[1] Yunnan Acad Tobacco Agr Sci, Kunming 650031, Yunnan, Peoples R China

[2] China Tobacco Yunnan Ind Co Ltd, Key Lab Tobacco Chem Yunnan Prov, Kunming 650231, Peoples R China

来源：

HETEROCYCLES | 2016年 / 92卷 / 02期

基金：

中国国家自然科学基金;

关键词：

SESQUITERPENE GLUCOSIDES; CURED TOBACCO; DERIVATIVES; CYTOTOXICITY; ROOTS; STEMS; FLAVONOIDS;

D O I：

10.3987/COM-15-13331

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new isoindolin-1-ones, 2-(2-hydroxyethyl)-5-methyl-6-(3-methylbut-2-enyl)isoindolin-1-one (1) and 2,5-dimethyl-6-(3-methylbut-2-enyl)isoindolin-1-one (2), were isolated from the leaves of Nicotiana tabacum. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (anti-TMV) activities. The results revealed that compounds 1 and 2 showed potential anti-TMV activities with inhibition rates of 48.2 and 45.6%, respectively.

引用

页码：331 / 336

页数：6

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