Bacterial Histidine Kinases as Novel Antibacterial Drug Targets

被引：153

作者：

Bem, Agnieszka E. ^{[1
]}

Velikova, Nadya ^{[2
]}

Teresa Pellicer, M. ^{[3
]}

van Baarlen, Peter ^{[1
]}

Marina, Alberto ^{[2
,4
]}

Wells, Jerry M. ^{[1
]}

机构：

[1] Wageningen Univ, NL-6708 WD Wageningen, Netherlands

[2] CSIC, IBV, Valencia 46010, Spain

[3] Ferrer HealthTech, R&D Dept Interquim, St Cugat Valles Barcelon 08137, Spain

[4] Ctr Invest Biomed Red Enfermedades Raras CIBER IS, Valencia 46010, Spain

来源：

ACS CHEMICAL BIOLOGY | 2015年 / 10卷 / 01期

关键词：

SIGNAL-TRANSDUCTION SYSTEMS; 2-COMPONENT REGULATORY SYSTEMS; STRUCTURE-BASED DISCOVERY; STAPHYLOCOCCUS-AUREUS; MYCOBACTERIUM-TUBERCULOSIS; MULTIDRUG-RESISTANCE; ESCHERICHIA-COLI; VANCOMYCIN RESISTANCE; STREPTOCOCCUS-MUTANS; BACILLUS-SUBTILIS;

D O I：

10.1021/cb5007135

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacterial histidine kinases (HKs) are promising targets for novel antibacterials. Bacterial HKs are part of bacterial two-component systems (TCSs), the main signal transduction pathways in bacteria, regulating various processes including virulence, secretion systems and antibiotic resistance. In this review, we discuss the biological importance of TCSs and bacterial HKs for the discovery of novel antibacterials, as well as published TCS and HK inhibitors that can be used as a starting point for structure-based approaches to develop novel antibacterials.

引用

页码：213 / 224

页数：12

共 50 条

[1] Bacterial tyrosine kinases: novel targets for antibacterial therapy?
Cozzone, Alain J.
TRENDS IN MICROBIOLOGY, 2009, 17 (12) : 536 - 543
[2] Protein kinases as antibacterial targets
Schreiber, Mark
Res, Ivica
Matter, Alex
CURRENT OPINION IN CELL BIOLOGY, 2009, 21 (02) : 325 - 330
[3] Bacterial surface appendages as targets for novel antibacterial therapeutics
Steadman, David
Lo, Alvin
Waksman, Gabriel
Remaut, Han
FUTURE MICROBIOLOGY, 2014, 9 (07) : 887 - 900
[4] Histidine kinases as antimicrobial targets: Prospects and pitfalls
Rowland, S. L.
King, G. F.
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2007, 7 (11) : 1144 - 1154
[5] Bacterial caseinolytic proteases as novel targets for antibacterial treatment
Broetz-Oesterhelt, Heike
Sass, Peter
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2014, 304 (01) : 23 - 30
[6] Histidine kinases as targets for new antimicrobial agents
Matsushita, M
Janda, KD
BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (04) : 855 - 867
[7] Bacterial fatty acid biosynthesis: Targets for antibacterial drug discovery
Campbell, JW
Cronan, JE
ANNUAL REVIEW OF MICROBIOLOGY, 2001, 55 : 305 - 332
[8] Bacterial DNA replication enzymes as targets for antibacterial drug discovery
Sanyal, Gautam
Doig, Peter
EXPERT OPINION ON DRUG DISCOVERY, 2012, 7 (04) : 327 - 339
[9] Peptide deformylase and LuxS as novel antibacterial drug targets
Pei, DH
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U536 - U537
[10] Novel Antibacterial Compounds and their Drug Targets - Successes and Challenges
Kaczor, Agnieszka A.
Polski, Andrzej
Sobotka-Polska, Karolina
Pachuta-Stec, Anna
Makarska-Bialokoz, Magdalena
Pitucha, Monika
CURRENT MEDICINAL CHEMISTRY, 2017, 24 (18) : 1948 - 1982

← 1 2 3 4 5 →