Bacterial Histidine Kinases as Novel Antibacterial Drug Targets

被引：155

作者：

Bem, Agnieszka E. ^{[1
]}

Velikova, Nadya ^{[2
]}

Teresa Pellicer, M. ^{[3
]}

van Baarlen, Peter ^{[1
]}

Marina, Alberto ^{[2
,4
]}

Wells, Jerry M. ^{[1
]}

机构：

[1] Wageningen Univ, NL-6708 WD Wageningen, Netherlands

[2] CSIC, IBV, Valencia 46010, Spain

[3] Ferrer HealthTech, R&D Dept Interquim, St Cugat Valles Barcelon 08137, Spain

[4] Ctr Invest Biomed Red Enfermedades Raras CIBER IS, Valencia 46010, Spain

来源：

ACS CHEMICAL BIOLOGY | 2015年 / 10卷 / 01期

关键词：

SIGNAL-TRANSDUCTION SYSTEMS; 2-COMPONENT REGULATORY SYSTEMS; STRUCTURE-BASED DISCOVERY; STAPHYLOCOCCUS-AUREUS; MYCOBACTERIUM-TUBERCULOSIS; MULTIDRUG-RESISTANCE; ESCHERICHIA-COLI; VANCOMYCIN RESISTANCE; STREPTOCOCCUS-MUTANS; BACILLUS-SUBTILIS;

D O I：

10.1021/cb5007135

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacterial histidine kinases (HKs) are promising targets for novel antibacterials. Bacterial HKs are part of bacterial two-component systems (TCSs), the main signal transduction pathways in bacteria, regulating various processes including virulence, secretion systems and antibiotic resistance. In this review, we discuss the biological importance of TCSs and bacterial HKs for the discovery of novel antibacterials, as well as published TCS and HK inhibitors that can be used as a starting point for structure-based approaches to develop novel antibacterials.

引用

页码：213 / 224

页数：12

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