Radiation dose constraints for organs at risk in neuro-oncology; the European Particle Therapy Network consensus

被引：127

作者：

Lambrecht, Maarten ^{[1
,2
]}

Eekers, Danielle B. P. ^{[3
,4
]}

Alapetite, Claire ^{[5
,6
]}

Burnet, Neil G. ^{[7
]}

Calugaru, Valentin ^{[5
,6
,8
]}

Coremans, Ida E. M. ^{[9
,10
]}

Fossati, Piero ^{[11
]}

Hoyer, Morten ^{[12
]}

Langendijk, Johannes A. ^{[13
]}

Romero, Alejandra Mendez ^{[10
,14
]}

Paulsen, Frank ^{[15
]}

Perpar, Ana ^{[11
]}

Renard, Laurette ^{[16
]}

de Ruysscher, Dirk ^{[3
,4
]}

Timmermann, Beate ^{[17
,18
,19
]}

Vitek, Pavel ^{[20
]}

Weber, Damien C. ^{[21
]}

van der Weide, Hiske L. ^{[13
]}

Whitfield, Gillian A. ^{[22
,23
]}

Wiggenraad, Ruud ^{[24
]}

Roelofs, Erik ^{[3
]}

Nystrom, Petra Witt ^{[12
,25
]}

Troost, Esther G. C. ^{[26
,27
,28
,29
,30
,31
,32
,33
]}

机构：

[1] Univ Hosp Gasthuisberg, Leuven Kanker Inst, Dept Radiotherapy Oncol, Leuven, Belgium

[2] Particle Therapy Interuniv Ctr Leuven PartICLe, Leuven, Belgium

[3] Maastricht Univ, Med Ctr, GROW Sch Oncol & Dev Biol, Dept Radiat Oncol MAASTRO, Maastricht, Netherlands

[4] Proton Therapy Dept South East Netherlands ZON PT, Maastricht, Netherlands

[5] Inst Curie, Dept Radiat Oncol, Paris, France

[6] Proton Ctr, Orsay, France

[7] Univ Cambridge, Dept Oncol, Addenbrookes Hosp, Cambridge Biomed Campus, Cambridge, England

[8] Inst Curie, Ctr Protontherapie Orsay, Paris, France

[9] Leiden Univ, Med Ctr, Dept Radiotherapy, Leiden, Netherlands

[10] Holland Proton Therapy Ctr, Delft, Netherlands

[11] EBG MedAustron GmbH, Wiener Neustadt, Austria

[12] Danish Ctr Particle Therapy, Aarhus, Denmark

[13] Univ Groningen, Univ Med Ctr Groningen, Dept Radiat Oncol, Groningen, Netherlands

[14] Erasmus MC, Rotterdam, Netherlands

[15] Eberhard Carls Univ Tubingen, Dept Radiat Oncol, Tubingen, Germany

[16] Clin Univ St Luc, Serv Radiotherapie Oncol, Brussels, Belgium

[17] Univ Hosp Essen, Clin Particle Therapy, West German Canc Ctr WTZ, Essen, Germany

[18] West German Proton Therapy Ctr Essen WPE, Essen, Germany

[19] German Canc Consortium DKTK, Partner Site Essen, Heidelberg, Germany

[20] Proton Therapy Ctr Czech, Prague, Czech Republic

[21] Paul Scherrer Inst, Med Ctr Proton Therapy, Villigen, Switzerland

[22] Univ Manchester, Manchester Acad Hlth Sci Ctr, Christie NHS Fdn Trust, Manchester, Lancs, England

[23] Univ Manchester, Royal Manchester Childrens Hosp, Childrens Brain Tumour Res Network, Manchester, Lancs, England

[24] Haaglanden Med Ctr, Dept Radiotherapy, Leidschendam, Netherlands

[25] Skand Clin, Uppsala, Sweden

[26] Tech Univ Dresden, Fac Med, Dept Radiotherapy & Radiat Oncol, Dresden, Germany

[27] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dresden, Germany

[28] Helmholtz Zentrum Dresden Rossendorf, Inst Radiooncol OncoRay, Dresden, Germany

[29] Tech Univ Dresden, Helmholtz Zentrum Dresden Rossendorf, Fac Med, OncoRay Natl Ctr Radiat Res Oncol, Dresden, Germany

[30] Tech Univ Dresden, Helmholtz Zentrum Dresden Rossendorf, Univ Hosp Carl Gustav Carus, Dresden, Germany

[31] German Canc Consortium DKTK, Partner Site Dresden, Heidelberg, Germany

[32] German Canc Res Ctr, Heidelberg, Germany

[33] Natl Ctr Tumor Dis NCT, Partner Site Dresden, Heidelberg, Germany

来源：

RADIOTHERAPY AND ONCOLOGY | 2018年 / 128卷 / 01期

关键词：

Dose constraints; Organs at risk; Particle therapy; European Particle Therapy Network; INTENSITY-MODULATED RADIOTHERAPY; SENSORINEURAL HEARING-LOSS; EXTERNAL-BEAM IRRADIATION; DRY-EYE SYNDROME; NASOPHARYNGEAL CARCINOMA; BRAIN-STEM; NORMAL TISSUE; PITUITARY DYSFUNCTION; CRANIAL IRRADIATION; OPTIC NEUROPATHY;

D O I：

10.1016/j.radonc.2018.05.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: For unbiased comparison of different radiation modalities and techniques, consensus on delineation of radiation sensitive organs at risk (OARs) and on their dose constraints is warranted. Following the publication of a digital, online atlas for OAR delineation in neuro-oncology by the same group, we assessed the brain OAR-dose constraints in a follow-up study. Methods: We performed a comprehensive search to identify the current papers on OAR dose constraints for normofractionated photon and particle therapy in PubMed, Ovid Medline, Cochrane Library, Embase and Web of Science. Moreover, the included articles' reference lists were cross-checked for potential studies that met the inclusion criteria. Consensus was reached among 20 radiation oncology experts in the field of neuro-oncology. Results: For the OARs published in the neuro-oncology literature, we summarized the available literature and recommended dose constraints associated with certain levels of normal tissue complication probability (NTCP) according to the recent ICRU recommendations. For those OARs with lacking or insufficient NTCP data, a proposal for effective and efficient data collection is given. Conclusion: The use of the European Particle Therapy Network-consensus OAR dose constraints summarized in this article is recommended for the model-based approach comparing photon and proton beam irradiation as well as for prospective clinical trials including novel radiation techniques and/or modalities. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：26 / 36

页数：11

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