Highly efficient antibacterial activity of graphene/chitosan/magnetite nanocomposites against ESBL-producing Pseudomonas aeruginosa and Klebsiella pneumoniae

被引：25

作者：

Maruthupandy, Muthuchamy ^{[1
]}

Rajivgandhi, Govindan ^{[2
,3
]}

Muneeswaran, Thillaichidambaram ^{[1
]}

Anand, Muthusamy ^{[4
]}

Quero, Franck ^{[1
,5
]}

机构：

[1] Univ Chile, Lab Nanocelulosa & Biomat, Dept Ingn Quim Biotecnol & Mat, Fac Ciencias Fis & Matemat, Ave Beauchef 851, Santiago 8370456, Chile

[2] Sun Yat Sen Univ, Guangdong Prov Key Lab Plant Resources, State Key Lab Biocontrol, Sch Life Sci, Guangzhou 510275, Peoples R China

[3] Sun Yat Sen Univ, Southern Marine Sci & Engn Guangdong Lab Zhuhai, Sch Life Sci, Guangzhou 510275, Peoples R China

[4] Madurai Kamaraj Univ, Dept Marine & Coastal Studies, Madurai 625021, Tamil Nadu, India

[5] Millennium Nucleus Smart Soft Mech Metamat, Ave Beauchef 851, Santiago 8370456, Chile

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2021年 / 202卷

关键词：

Hydrothermal synthesis; Graphene; Chitosan; Magnetite; Nanocomposites; Antibacterial activity; SPECTRUM BETA-LACTAMASES; MULTIDRUG-RESISTANT BACTERIA; GRAPHENE; NANOPARTICLES; METAL; CYTOTOXICITY; PERFORMANCE; ADSORPTION; MECHANISM; CHITOSAN;

D O I：

10.1016/j.colsurfb.2021.111690

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

In the present study, chitosan-containing nanocomposites were investigated as new antibacterial agents. Magnetite (Fe3O4) nanoparticles (NPs) as well as chitosan (CS)/Fe3O4 nanocomposites (NCs) and graphene(Gr)/ CS/Fe3O4 NCs were synthesized by simple hydrothermal method. Their composition, structure and morphology were studied, followed by the evaluation of their antibacterial activity against ESBL-producing and gramnegative P. aeruginosa and K. pneumoniae bacterial strains. The Gr/CS/Fe3O4 NCs showed significantly higher antibacterial activity compared to Fe3O4 NPs and CS/Fe3O4 NCs (105 and 69 % higher against P. aeruginosa as well as 91 and 77 % higher against K. pneumoniae, respectively). The minimum inhibitory concentration (MIC) of Gr/CS/Fe3O4 NCs against P. aeruginosa and K. pneumoniae were 60 and 70 mu g/mL, respectively. The synergistic antibacterial activity and facile synthesis of Gr/CS/Fe3O4 NCs suggests their applicability as novel highly efficient antibacterial agents with potential for a wide range of biomedical applications, where antibacterial properties are needed.

引用

页数：12

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