The Natural Flavonoid Pinocembrin: Molecular Targets and Potential Therapeutic Applications

被引：88
|
作者：
Lan, Xi [1 ]
Wang, Wenzhu [1 ]
Li, Qiang [1 ]
Wang, Jian [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, 720 Rutland Ave,Ross Bldg 370B, Baltimore, MD 21205 USA
来源：
MOLECULAR NEUROBIOLOGY | 2016年 / 53卷 / 03期
关键词：
Neuroinflammation; Neuroprotection; Pinocembrin; Stroke; SOLUBLE EPOXIDE HYDROLASE; BLOOD-BRAIN-BARRIER; ESCHERICHIA-COLI; NEUROVASCULAR UNIT; CEREBRAL-ISCHEMIA; IN-VITRO; COMBINATORIAL BIOSYNTHESIS; ANTIMICROBIAL ACTIVITY; INDUCED APOPTOSIS; SH-SY5Y CELLS;
D O I：
10.1007/s12035-015-9125-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Pinocembrin is a natural flavonoid compound extracted from honey, propolis, ginger roots, wild marjoram, and other plants. In preclinical studies, it has shown anti-inflammatory and neuroprotective effects as well as the ability to reduce reactive oxygen species, protect the blood-brain barrier, modulate mitochondrial function, and regulate apoptosis. Considering these pharmaceutical characteristics, pinocembrin has potential as a drug to treat ischemic stroke and other clinical conditions. In this review, we summarize its pharmacologic characteristics and discuss its mechanisms of action and potential therapeutic applications.
引用
收藏
页码：1794 / 1801
页数：8
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