Risk prediction model for disease-free survival in women with early-stage cervical cancers following postoperative (chemo)radiotherapy

被引：8

作者：

Je, Hyoung Uk ^{[1
]}

Han, Seungbong ^{[2
]}

Kim, Young Seok ^{[3
]}

Nam, Joo-Hyun ^{[4
]}

Park, Won ^{[5
]}

Song, Sanghyuk ^{[6
]}

Song, Changhoon ^{[7
]}

Kim, Jin Hee ^{[8
]}

Kim, Juree ^{[9
,10
]}

Yoon, Won Sup ^{[11
]}

Yoon, Mee Sun ^{[12
]}

Choi, Jin Hwa ^{[13
]}

Kim, Joo-Young ^{[14
]}

机构：

[1] Univ Ulsan, Coll Med, Ulsan Univ Hosp, Dept Radiat Oncol, Ulsan, South Korea

[2] Gachon Univ, Dept Appl Stat, Gyeonggi Do, South Korea

[3] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Radiat Oncol, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea

[4] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Obstet & Gynecol, Seoul, South Korea

[5] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Radiat Oncol, Seoul, South Korea

[6] Kangwon Natl Univ Hosp, Dept Radiat Oncol, Gangwon Do, South Korea

[7] Seoul Natl Univ, Bundang Hosp, Dept Radiat Oncol, Gyeonggi Do, South Korea

[8] Keimyung Univ, Sch Med, Dongsan Med Ctr, Dept Radiat Oncol, Daegu, South Korea

[9] Dankook Univ, Cheil Gen Hosp, Dept Radiat Oncol, Seoul, South Korea

[10] Dankook Univ, Coll Med, Womens Healthcare Ctr, Seoul, South Korea

[11] Korea Univ, Ansan Hosp, Dept Radiat Oncol, Gyeonggi Do, South Korea

[12] Chonnam Natl Univ, Hwasun Hosp, Med Sch, Dept Radiat Oncol, Jeollanam Do, South Korea

[13] Chung Ang Univ Hosp, Dept Radiat Oncol, Seoul, South Korea

[14] Natl Canc Ctr, Res Inst & Hosp, Ctr Uterine Canc, Gyeonggi Do, South Korea

来源：

TUMORI JOURNAL | 2018年 / 104卷 / 02期

关键词：

Adjuvant radiation therapy; Disease-free survival; Uterine cervical cancer;

D O I：

10.5301/tj.5000697

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: To investigate disease-free survival (DFS) and prognostic factors following the administration of postoperative (chemo) radiotherapy in patients with early-stage cervical cancers. Methods: The medical records of 1,069 patients from 10 participating institutions were reviewed. Statistically and clinically established factors were considered as candidates for constructing the prediction model. This model was validated, using bootstrapping to correct for optimistic bias. Results: The 5-year DFS rate was 81.1%, with a median follow-up period of 59.6 months. The statistically significant prognostic factors were as follows: pelvic lymph node metastasis, histologic type, parametrial invasion, lymphovascular space invasion, and tumor size. The nomogram for DFS was constructed, and it demonstrated a good discrimination performance, with an internally validated concordance index of 0.72. Conclusions: Our predictive model exhibited accurate predictions and may be useful in designing clinical trials to study if further chemotherapy can reduce the recurrence of disease in high-risk patients.

引用

页码：105 / 110

页数：6

共 27 条

[1]

Peters W.A., Liu P.Y., Barrett R.J., Et al., Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix, J Clin Oncol, 18, 8, pp. 1606-1613, (2000)

[2]

Rotman M., Sedlis A., Piedmonte M.R., Et al., A phase III randomized trial of postoperative pelvic irradiation in Stage IB cervical carcinoma with poor prognostic features: Follow-up of a gynecologic oncology group study, Int J Radiat Oncol Biol Phys, 65, 1, pp. 169-176, (2006)

[3]

Sedlis A., Bundy B.N., Rotman M.Z., Lentz S.S., Muderspach L.I., Zaino R.J., A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study, Gynecol Oncol, 73, 2, pp. 177-183, (1999)

[4]

Kim H.J., Rhee W.J., Choi S.H., Et al., Clinical outcomes of adjuvant radiation therapy and prognostic factors in early stage uterine cervical cancer, Radiat Oncol J, 33, 2, pp. 126-133, (2015)

[5]

Yang K., Park W., Huh S.J., Bae D.S., Kim B.G., Lee J.W., Clinical outcomes in patients treated with radiotherapy after surgery for cervical cancer, Radiat Oncol J, 35, 1, pp. 39-47, (2017)

[6]

van Nagell J.R., Roddick J.W., Lowin D.M., The staging of cervical cancer: Inevitable discrepancies between clinical staging and pathologic findinges, Am J Obstet Gynecol, 110, 7, pp. 973-978, (1971)

[7]

Je H.U., Han S., Kim Y.S., Et al., A nomogram predicting the risks of distant metastasis following postoperative radiotherapy for uterine cervical carcinoma: A Korean radiation oncology group study (KROG 1208), Radiother Oncol, 111, 3, pp. 437-441, (2014)

[8]

Kim M.K., Jo H., Kong H.J., Et al., Postoperative nomogram predicting risk of recurrence after radical hysterectomy for early-stage cervical cancer, Int J Gynecol Cancer, 20, 9, pp. 1581-1586, (2010)

[9]

Lee H.J., Han S., Kim Y.S., Et al., Individualized prediction of overall survival after postoperative radiation therapy in patients with early-stage cervical cancer: A Korean Radiation Oncology Group study (KROG 1303), Int J Radiat Oncol Biol Phys, 87, 4, pp. 659-664, (2013)

[10]

Polterauer S., Grimm C., Hofstetter G., Et al., Nomogram prediction for overall survival of patients diagnosed with cervical cancer, Br J Cancer, 107, 6, pp. 918-924, (2012)

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