Photostability of drugs: photodegradation of melatonin and its determination in commercial formulations

被引：42

作者：

Andrisano, V

Bertucci, C

Battaglia, A

Cavrini, V

机构：

[1] Univ Bologna, Dipartimento Sci Farmaceut, I-40126 Bologna, Italy

[2] CMSOA, CNR, Dipartimento Chim & Chim Ind, Pisa, Italy

[3] Icocea, Ist CNR, Bologna, Italy

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2000年 / 23卷 / 01期

关键词：

melatonin; photostability; liquid chromatography (HPLC); photoproduct characterisation; formulation quality control;

D O I：

10.1016/S0731-7085(00)00259-4

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The photostability of melatonin, a hormone used as supplementary drug in the alleviation of jet-lag and other sleep disorders, was studied. The drug photodegradation at different pH values was monitored by HPLC methods. The main photoproduct was isolated and characterised on the basis of the NMR, FTIR, and mass spectra. A HPLC method, in combination with a post-column on-line photochemical derivatisation was developed for the selective and reliable quality control of commercially available melatonin containing products. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：15 / 23

页数：9

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