Rhodium-catalyzed tandem C-H activation and aza-Michael addition of 2-arylquinazolin-4-ones with acrylates for the synthesis of pyrrolo[2,1-b]quinazolin-9(1H)-one derivatives

被引：31

作者：

Jiang, Xin ^{[1
,2
]}

Yang, Qin ^{[1
,2
]}

Yuan, Jianjun ^{[1
,2
]}

Deng, Zhihong ^{[1
,2
]}

Mao, Xuechun ^{[1
,2
]}

Peng, Yiyuan ^{[1
,2
]}

Yu, Chuyi ^{[3
]}

机构：

[1] Minist Educ, Jiangxi Provinces Key Lab Green Chem, Key Lab Funct Small Organ Mol, Nanchang 330022, Peoples R China

[2] Jiangxi Normal Univ, Nanchang 330022, Peoples R China

[3] Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 330022, Peoples R China

来源：

TETRAHEDRON | 2016年 / 72卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Rhodium catalysis; C-H activation; Aza-Michael addition; Quinazolin-4-one; Pyrrolo[2,1-b]quinazolin-9(1H)-one; Tandem reaction; DIELS-ALDER REACTION; BOND FORMATION; QUINAZOLINE; QUINOLINE;

D O I：

10.1016/j.tet.2016.01.020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this paper, a rhodium-catalyzed reaction of 2-arylquinazolin-4-ones with acrylates is described, leading to pyrrolo[2, 1-b]quinazolin-9(1H)-one derivatives with high efficiency and good tolerance of functional groups. In the reactions, it is believed that tandem C-H activation and aza-Michael addition are involved. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：1238 / 1243

页数：6

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