Rhodium-catalyzed tandem C-H activation and aza-Michael addition of 2-arylquinazolin-4-ones with acrylates for the synthesis of pyrrolo[2,1-b]quinazolin-9(1H)-one derivatives

被引：30
|
作者：
Jiang, Xin [1 ,2 ]
Yang, Qin [1 ,2 ]
Yuan, Jianjun [1 ,2 ]
Deng, Zhihong [1 ,2 ]
Mao, Xuechun [1 ,2 ]
Peng, Yiyuan [1 ,2 ]
Yu, Chuyi [3 ]
机构：
[1] Minist Educ, Jiangxi Provinces Key Lab Green Chem, Key Lab Funct Small Organ Mol, Nanchang 330022, Peoples R China
[2] Jiangxi Normal Univ, Nanchang 330022, Peoples R China
[3] Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 330022, Peoples R China
来源：
TETRAHEDRON | 2016年 / 72卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Rhodium catalysis; C-H activation; Aza-Michael addition; Quinazolin-4-one; Pyrrolo[2,1-b]quinazolin-9(1H)-one; Tandem reaction; DIELS-ALDER REACTION; BOND FORMATION; QUINAZOLINE; QUINOLINE;
D O I：
10.1016/j.tet.2016.01.020
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this paper, a rhodium-catalyzed reaction of 2-arylquinazolin-4-ones with acrylates is described, leading to pyrrolo[2, 1-b]quinazolin-9(1H)-one derivatives with high efficiency and good tolerance of functional groups. In the reactions, it is believed that tandem C-H activation and aza-Michael addition are involved. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1238 / 1243
页数：6
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