The Role of the Gut-Brain Axis in Attention-Deficit/Hyperactivity Disorder

被引：48

作者：

Dam, Sarita A. ^{[1
]}

Mostert, Jeanette C. ^{[2
]}

Szopinska-Tokov, Joanna W. ^{[3
]}

Bloemendaal, Miriam ^{[3
]}

Amato, Maria ^{[2
]}

Arias-Vasquez, Alejandro ^{[2
,3
]}

机构：

[1] Radboud Univ Nijmegen Med Ctr, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, Kapittelweg 29, NL-6525 EN Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Human Genet, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Psychiat, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2019年 / 48卷 / 03期

关键词：

Gut-brain axis; Endocrine communication; Immunology; Metabolites; Nerval communication; Biomarkers; ADHD; Genetics; DEFICIT HYPERACTIVITY DISORDER; ENVIRONMENTAL RISK-FACTORS; LOCUS-COERULEUS; DSM-IV; AMINOBUTYRIC-ACID; VAGAL AFFERENTS; CANDIDATE GENE; VAGUS NERVE; FATTY-ACIDS; ADULT ADHD;

D O I：

10.1016/j.gtc.2019.05.001

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Genetic and environmental factors play a role in the cause and development of attention-deficit/hyperactivity disorder (ADHD). Recent studies have suggested an important role of the gut-brain axis (GBA) and intestinal microbiota in modulating the risk of ADHD. Here, the authors provide a brief overview of the clinical and biological picture of ADHD and how the GBA could be involved in its cause. They discuss key biological mechanisms involved in the GBA and how these may increase the risk of developing ADHD. Understanding these mechanisms may help to characterize novel treatment options via identification of disease biomarkers.

引用

页码：407 / +

页数：26

共 204 条

[1] Serum concentrations of kynurenines in adult patients with attention-deficit hyperactivity disorder (ADHD): a case-control study [J].