High Usage of Topical Fusidic Acid and Rapid Clonal Expansion of Fusidic Acid-Resistant Staphylococcus aureus: A Cautionary Tale

被引：65

作者：

Williamson, Deborah A. ^{[1
,2
,3
]}

Monecke, Stefan ^{[4
,5
]}

Heffernan, Helen ^{[2
]}

Ritchie, Stephen R. ^{[1
]}

Roberts, Sally A. ^{[6
]}

Upton, Arlo ^{[7
]}

Thomas, Mark G. ^{[1
]}

Fraser, John D. ^{[1
,3
]}

机构：

[1] Univ Auckland, Dept Mol Med & Pathol, Auckland, New Zealand

[2] Inst Environm Sci & Res, Wellington, New Zealand

[3] Maurice Wilkins Ctr Mol Biodiscovery, Auckland, New Zealand

[4] Alere Technol, Jena, Germany

[5] Inst Med Microbiol & Hyg, Dresden, Germany

[6] Auckland Dist Hlth Board, Dept Clin Microbiol, Auckland, New Zealand

[7] LabTests, Auckland, New Zealand

来源：

CLINICAL INFECTIOUS DISEASES | 2014年 / 59卷 / 10期

关键词：

antimicrobial use; antimicrobial resistance; epidemiology; fusC; MRSA; MECHANISMS; SPP;

D O I：

10.1093/cid/ciu658

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Our aim was to assess national prescribing trends and determine longitudinal resistance patterns for topical antimicrobials in New Zealand. We observed a dramatic increase in fusidic acid (FA) resistance, and clonal expansion of FA-resistant Staphylococcus aureus. This increase was concurrent with a significant national increase in topical FA dispensing.

引用

页码：1451 / 1454

页数：4

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