Unnatural oligomers and unnatural oligomer libraries

被引：58

作者：

Soth, MJ ^{[1
]}

Nowick, JS ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1997年 / 1卷 / 01期

关键词：

D O I：

10.1016/S1367-5931(97)80118-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Within the past few years, a variety of compounds that mimic biopolymers have been developed. All of these unnatural oligomers are prepared by iterative syntheses, which are amenable to combinatorial strategies. Peptides continue to be popular targets for mimicry, and there is growing interest in targeting oligosaccharides. The incorporation of unnatural oligomers into compounds that adopt defined structures, such as he(ices or sheets, has emerged as an exciting new area of unnatural oligomer research.

引用

收藏

页码：120 / 129

页数：10

相关论文

共 60 条

[1] Synthesis of propane-2,3-diol combinatorial monomers [J].

Acevedo, OL ;

Andrews, RS .

TETRAHEDRON LETTERS, 1996, 37 (23) :3931-3934

[2] beta-peptide foldamers: Robust Helix formation in a new family of beta-amino acid oligomers [J].

Appella, DH ;

Christianson, LA ;

Karle, IL ;

Powell, DR ;

Gellman, SH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (51) :13071-13072

[3] PEPTIDOSTEROIDAL RECEPTORS FOR OPIOID-PEPTIDES - SEQUENCE-SELECTIVE BINDING USING A SYNTHETIC RECEPTOR LIBRARY [J].

BOYCE, R ;

LI, G ;

NESTLER, HP ;

SUENAGA, T ;

STILL, WC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (17) :7955-7956

[4] Nanometre-scale molecular ribbons [J].

Breidenbach, S ;

Ohren, S ;

Vogtle, F .

CHEMISTRY-A EUROPEAN JOURNAL, 1996, 2 (07) :832-837

[5]

Breidenbach S, 1996, LIEBIGS ANN, P2115

[6] SOLID-PHASE SYNTHESES OF UNNATURAL BIOPOLYMERS CONTAINING REPEATING UREA UNITS [J].

BURGESS, K ;

LINTHICUM, DS ;

SHIN, HW .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1995, 34 (08) :907-909

[7] COMPLEMENTARY ENANTIOSPECIFIC SYNTHESES OF CONDURITOL-E EPOXIDES FROM HALOBENZENES [J].

CARLESS, HAJ .

TETRAHEDRON LETTERS, 1992, 33 (42) :6379-6382

[8] Sequence-selective peptide binding with a peptido-A,B-trans-steroidal receptor selected from an encoded combinatorial receptor library [J].

Cheng, YA ;

Suenaga, T ;

Still, WC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (07) :1813-1814

[9] AN UNNATURAL BIOPOLYMER [J].

CHO, CY ;

MORAN, EJ ;

CHERRY, SR ;

STEPHANS, JC ;

FODOR, SPA ;

ADAMS, CL ;

SUNDARAM, A ;

JACOBS, JW ;

SCHULTZ, PG .

SCIENCE, 1993, 261 (5126) :1303-1305

[10] DRUG LEADS FROM COMBINATORIAL PHOSPHODIESTER LIBRARIES [J].

DAVIS, PW ;

VICKERS, TA ;

WILSONLINGARDO, L ;

WYATT, JR ;

GUINOSSO, CJ ;

SANGHVI, YS ;

DEBAETS, EA ;

ACEVEDO, OL ;

COOK, PD ;

ECKER, DJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (22) :4363-4366

← 1 2 3 4 5 6 →