IUGR Does Not Predispose to Necrotizing Enterocolitis or Compromise Postnatal Intestinal Adaptation in Preterm Pigs

被引:44
作者
Che, Lianqiang [2 ]
Thymann, Thomas
Bering, Stine B.
Le Huerou-Luron, Isabelle [3 ,4 ]
D'Inca, Romain [3 ,4 ]
Zhang, Keying [2 ]
Sangild, Per T. [1 ]
机构
[1] Univ Copenhagen, Dept Human Nutr, Fac Life Sci, DK-1958 Copenhagen, Denmark
[2] Sichuan Agr Univ, Inst Anim Nutr, Chengdu 625014, Sichuan, Peoples R China
[3] SENAH, UMR 1079, INRA, F-35590 St Gilles, France
[4] Agrocampus Ouest, UMR 1079, SENAH, F-35000 Rennes, France
关键词
INTRAUTERINE GROWTH RESTRICTION; LOW-BIRTH-WEIGHT; GASTROINTESTINAL-TRACT; PARENTERAL-NUTRITION; ENTERAL NUTRITION; NEWBORN PIGS; MORTALITY; MORBIDITY; INFANTS; OUTCOMES;
D O I
10.1203/PDR.0b013e3181c1b15e
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
IUGR and preterm birth are leading causes of neonatal morbidity. We tested the hypothesis that IUGR predisposes to gut maladaption and necrotizing enterocolitis (NEC) using preterm pigs as models for preterm infants. First, full-term normal birth weight (NW) and IUGR (similar to 65% of NW) pigs were compared. IUGR reduced intestinal weight per length, proportion mucosa, villous area, and sucrase activity at 2 d after birth (p < 0.05) but did not change relative organ weights. Next, groups of preterm pigs were fed formula or colostrum, starting at birth or after 2-3 d of total parenteral nutrition (TPN). Neonatal mortality (not related to NEC) was increased in IUGR versus NW preterm pigs (28 vs 10%, p < 0.01). NEC incidence was similar between IUGR and NW but higher after formula than colostrum feeding (46 vs 12%, p < 0.01) and higher after TPN than without TPN (61 vs 34% for formula pigs, p < 0.01). After feeding, relative intestinal mass and length were higher in IUGR versus NW pigs (+25-80%, p < 0.05) while brush border enzyme activities were similar. An enhanced gut trophic response to enteral feeding, may help to improve postnatal intestinal adaptation and NEC resistance in preterm IUGR newborns. (Pediatr Res 67: 54-59, 2010)
引用
收藏
页码:54 / 59
页数:6
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