Synthesis of novel quinone-amino acid hybrids via cross-enyne metathesis and Diels-Alder reaction as key steps

被引：40

作者：

Kotha, Sambasivarao ^{[1
]}

Mandal, Kalyaneswar ^{[1
]}

Banerjee, Shaibal ^{[1
]}

Mobin, Shaikh M. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 2007卷 / 08期

关键词：

quinone-amino acid hybrids; cross-enyne metathesis; cycloaddition; fullerenes;

D O I：

10.1002/ejoc.200600970

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A "Building Block Approach" for the synthesis of various quinone-amino acid hybrids through ethylene cross-enyne metathesis and Diels-Alder reaction as key steps is described. A library of comformationally constrained quinone-based phenylalanine derivatives and dicarba analogs of cystine have been generated starting from a common precursor using Grubbs' catalysts. This methodology has also been extended for the synthesis of fullerene-based dicarba analogs of cystine. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007).

引用

页码：1244 / 1255

页数：12

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