Emerging Role of Ferroptosis in Acute Kidney Injury

被引：153

作者：

Hu, Zhaoxin ^{[1
]}

Zhang, Hao ^{[1
]}

Yang, Shi-kun ^{[1
]}

Wu, Xueqin ^{[1
]}

He, Dong ^{[2
]}

Cao, Ke ^{[3
]}

Zhang, Wei ^{[1
]}

机构：

[1] Cent S Univ, Xiangya Hosp 3, Dept Nephrol, Changsha 410013, Hunan, Peoples R China

[2] Hunan Univ Chinese Med, Peoples Hosp Hunan Prov 2, Dept Respirat, Changsha, Hunan, Peoples R China

[3] Cent S Univ, Xiangya Hosp 3, Dept Oncol, Changsha 410013, Hunan, Peoples R China

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2019年 / 2019卷

关键词：

ACUTE-RENAL-FAILURE; REGULATED CELL-DEATH; IN-VIVO EVIDENCE; FOLIC-ACID; CYSTINE/GLUTAMATE ANTIPORTER; LIPID-PEROXIDATION; OXIDATIVE STRESS; HEME OXYGENASE-1; SYSTEM X(C)(-); IRON;

D O I：

10.1155/2019/8010614

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Acute kidney injury (AKI) is a heterogeneous group of critical disease conditions with high incidence and mortality. Vasoconstriction, oxidative stress, apoptosis, and inflammation are generally thought to be the main pathogenic mechanisms of AKI. Ferroptosis is a type of iron-dependent nonapoptotic cell death characterized by membrane lipid peroxide accumulation and polyunsaturated fatty acid consumption, and it plays essential roles in many diseases, including cancers and neurologic diseases. Recent studies have revealed an emerging role of ferroptosis in the pathophysiological processes of AKI. Here, in the present review, we summarized the most recent discoveries on the role of ferroptosis in the pathogenesis of AKI as well as its therapeutic potential in AKI.

引用

页数：8

共 81 条

[1]

Agarwal A, 2000, J AM SOC NEPHROL, V11, P965, DOI 10.1681/ASN.V115965

[2] NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis [J].

Alvarez, Samantha W. ;

Sviderskiy, Vladislav O. ;

Terzi, Erdem M. ;

Papagiannakopoulos, Thales ;

Moreira, Andre L. ;

Adams, Sylvia ;

Sabatini, David M. ;

Birsoy, Kivanc ;

Possemato, Richard .

NATURE, 2017, 551 (7682) :639-+

[3] Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice [J].

Angeli, Jose Pedro Friedmann ;

Schneider, Manuela ;

Proneth, Bettina ;

Tyurina, Yulia Y. ;

Tyurin, Vladimir A. ;

Hammond, Victoria J. ;

Herbach, Nadja ;

Aichler, Michaela ;

Walch, Axel ;

Eggenhofer, Elke ;

Basavarajappa, Devaraj ;

Radmark, Olof ;

Kobayashi, Sho ;

Seibt, Tobias ;

Beck, Heike ;

Neff, Frauke ;

Esposito, Irene ;

Wanke, Ruediger ;

Foerster, Heidi ;

Yefremova, Olena ;

Heinrichmeyer, Marc ;

Bornkamm, Georg W. ;

Geissler, Edward K. ;

Thomas, Stephen B. ;

Stockwell, Brent R. ;

O'Donnell, Valerie B. ;

Kagan, Valerian E. ;

Schick, Joel A. ;

Conrad, Marcus .

NATURE CELL BIOLOGY, 2014, 16 (12) :1180-U120

[4] INTRARENAL HEMODYNAMICS IN GLYCEROL-INDUCED MYOHEMOGLOBINURIC ACUTE RENAL FAILURE IN RAT [J].

AYER, G ;

GRANDCHAMP, A ;

WYLER, T ;

TRUNIGER, B .

CIRCULATION RESEARCH, 1971, 29 (02) :128-+

[5] In vitro and in vivo evidence suggesting a role for iron in cisplatin-induced nephrotoxicity [J].

Baliga, R ;

Zhang, ZW ;

Baliga, M ;

Ueda, N ;

Shah, SV .

KIDNEY INTERNATIONAL, 1998, 53 (02) :394-401

[6] Oxidant mechanisms in toxic acute renal failure [J].

Baliga, R ;

Ueda, N ;

Walker, PD ;

Shah, SV .

AMERICAN JOURNAL OF KIDNEY DISEASES, 1997, 29 (03) :465-477

[7] ROLE OF MEMBRANE-TRANSPORT IN METABOLISM AND FUNCTION OF GLUTATHIONE IN MAMMALS [J].

BANNAI, S ;

TATEISHI, N .

JOURNAL OF MEMBRANE BIOLOGY, 1986, 89 (01) :1-8

[8]

BANNAI S, 1986, J BIOL CHEM, V261, P2256

[9] Acute kidney injury [J].

Bellomo, Rinaldo ;

Kellum, John A. ;

Ronco, Claudio .

LANCET, 2012, 380 (9843) :756-766

[10] Current Concepts: Rhabdomyolysis and Acute Kidney Injury. [J].

Bosch, Xavier ;

Poch, Esteban ;

Grau, Josep M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (01) :62-72

← 1 2 3 4 5 6 7 8 9 →