A new cinnamamide derivative and two new β-carboline alkaloids from the stems of Picrasma quassioides

被引：14
作者：
Zhang, Jie [1 ]
Wang, Chuan-Xi [2 ]
Song, Xiao-Jun [1 ]
Li, Shuang [1 ]
Fan, Cai-Lian [1 ]
Chen, Guo-Dong [2 ]
Hu, Dan [2 ]
Yao, Xin-Sheng [1 ,2 ]
Gao, Hao [1 ,2 ]
机构：
[1] Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Liaoning, Peoples R China
[2] Jinni Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam ConstiMents, Guangzhou 510632, Guangdong, Peoples R China
来源：
FITOTERAPIA | 2019年 / 139卷
基金：
中国国家自然科学基金;
关键词：
Cinnamamide; beta-Carboline; Picrasma quassioides; AChE inhibitory activity; Antimicrobial activity; BENNET; CONSTITUENTS; PLANTS;
D O I：
10.1016/j.fitote.2019.104375
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Picrasamide A (1), a new cinnamamide derivative, together with two new beta-carboline alkaloids (2 and 3) and five known beta-carboline alkaloids (4-8) were isolated from the stems of Picrasma quassioides (D. Don) Benn. Their structures were elucidated by detailed analyses of UV, IR, HRESIMS, and NMR data. Compound 1 was the first case of cinnamamide derivative from genus Picrasma. The AChE inhibitory activity and the antimicrobial activity of 1-8 were assessed. In addition, preliminary structure-activity relationships of these beta-carboline alkaloids on the AChE inhibitory activity and antimicrobial activity were proposed.
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页数：5
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