A new cinnamamide derivative and two new β-carboline alkaloids from the stems of Picrasma quassioides

被引：14

作者：

Zhang, Jie ^{[1
]}

Wang, Chuan-Xi ^{[2
]}

Song, Xiao-Jun ^{[1
]}

Li, Shuang ^{[1
]}

Fan, Cai-Lian ^{[1
]}

Chen, Guo-Dong ^{[2
]}

Hu, Dan ^{[2
]}

Yao, Xin-Sheng ^{[1
,2
]}

Gao, Hao ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Liaoning, Peoples R China

[2] Jinni Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam ConstiMents, Guangzhou 510632, Guangdong, Peoples R China

来源：

FITOTERAPIA | 2019年 / 139卷

基金：

中国国家自然科学基金;

关键词：

Cinnamamide; beta-Carboline; Picrasma quassioides; AChE inhibitory activity; Antimicrobial activity; BENNET; CONSTITUENTS; PLANTS;

D O I：

10.1016/j.fitote.2019.104375

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Picrasamide A (1), a new cinnamamide derivative, together with two new beta-carboline alkaloids (2 and 3) and five known beta-carboline alkaloids (4-8) were isolated from the stems of Picrasma quassioides (D. Don) Benn. Their structures were elucidated by detailed analyses of UV, IR, HRESIMS, and NMR data. Compound 1 was the first case of cinnamamide derivative from genus Picrasma. The AChE inhibitory activity and the antimicrobial activity of 1-8 were assessed. In addition, preliminary structure-activity relationships of these beta-carboline alkaloids on the AChE inhibitory activity and antimicrobial activity were proposed.

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页数：5

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