A new cinnamamide derivative and two new β-carboline alkaloids from the stems of Picrasma quassioides

Picrasamide A (1), a new cinnamamide derivative, together with two new beta-carboline alkaloids (2 and 3) and five known beta-carboline alkaloids (4-8) were isolated from the stems of Picrasma quassioides (D. Don) Benn. Their structures were elucidated by detailed analyses of UV, IR, HRESIMS, and NMR data. Compound 1 was the first case of cinnamamide derivative from genus Picrasma. The AChE inhibitory activity and the antimicrobial activity of 1-8 were assessed. In addition, preliminary structure-activity relationships of these beta-carboline alkaloids on the AChE inhibitory activity and antimicrobial activity were proposed.