Progressive accumbens degeneration after neonatal striatal 6-hydroxydopamine in rats

被引：7

作者：

Teicher, MH

Andersen, SL

Campbell, A

Gelbard, HA

Baldessarini, RJ

机构：

[1] McLean Hosp, Psychiat Res Labs, Dev Psychopharmacol Lab, Mailman Res Ctr, Belmont, MA 02178 USA

[2] Harvard Univ, Sch Med, Consolidated Dept Psychiat, Boston, MA USA

[3] Harvard Univ, Sch Med, Neurosci Program, Boston, MA 02115 USA

[4] McLean Hosp, Psychiat Res Labs, Neuropharmacol Lab, Mailman Res Ctr, Belmont, MA 02178 USA

来源：

NEUROSCIENCE LETTERS | 1998年 / 247卷 / 2-3期

关键词：

caudate-putamen; 6-hydroxydopamine; models; nucleus accumbens septi; Parkinson's disease;

D O I：

10.1016/S0304-3940(98)00281-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Parkinson's disease is associated with progressive loss of nigrostriatal dopamine (DA). Models of the disorder, produced with neurotoxins (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or 6-hydroxydopamine) that selectively lesion DA neurons, are characterized by acute removal and gradual recovery of DA. We report slowly progressive loss of DA in ipsilateral nucleus accumbens following profound (>90%) acute unilateral depletion of DA in the caudate-putamen of neonatal rats, from 50% at age 27 days to 94% by 100 days. Metabolic turnover of DA markedly increased in ipsilateral accumbens, and may yield tissue-damaging neurotoxic by-products. This paradigm may help in elucidating mechanisms responsible for gradual degeneration of DA neurons and for screening potential neuroprotective agents. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：99 / 102

页数：4

共 20 条

[1] [H-3] SPIPERONE BINDING, DOPAMINE AND HVA CONCENTRATIONS IN PARKINSONS-DISEASE AND SUPRANUCLEAR PALSY [J].