Ca2+ Ions Regulate Activity of Na+,Cl-(HCO 3 - )-ATPase in the Mucosa of Rabbit Small Intestine

被引：3
作者：
Yurkiv, V. A. [1 ]
Melikhov, V. I. [1 ]
Shubin, V. S. [1 ]
机构：
[1] Minist Publ Hlth Russia, Cent Res Inst Epidemiol, Lab Mol Mech Infect, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2015年 / 158卷 / 03期
关键词：
secretory process; small intestine; transport ATPase; CFTR; CFTR; TRANSPORT; COLON; NHE3;
D O I：
10.1007/s10517-015-2753-8
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effects of bivalent metal ions on activity of Na+,Cl-(HCO3 (-))-ATPase was studied. In contrast to Ba2+, Co2+, Zn2+, and Mn2+ ions, Ca2+ and Mg2+ ions in a concentration of 0.25 mM completely inhibited this enzyme. Histamine in vivo significantly decreased the inhibiting effect of Ca2+ on Na+,Cl-(HCO3 (-))-ATPase. A possible mechanism of regulation of enzyme activity by Ca2+ ions and its possible relation with CFTR protein providing permeability of enterocyte apical membrane for Cl- ions was proposed.
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页码：326 / 328
页数：3
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