Secoiridoid Glycoside from the Flowers of Osmanthus fragrans var. aurantiacus Makino Inhibited the Activity of β-Secretase

被引：10

作者：

Lee, Do-Gyeong ^{[1
,2
]}

Choi, Jin-Sung ^{[3
]}

Yeon, Seung-Woo ^{[3
]}

Cui, En-Ji ^{[1
,2
]}

Park, Hee-Jung ^{[1
,2
]}

Yoo, Jong-Su ^{[3
]}

Chung, In-Sik ^{[1
,2
]}

Baek, Nam-In ^{[1
,2
]}

机构：

[1] Kyung Hee Univ, Grad Sch Biotechnol, Yongin 446701, South Korea

[2] Kyung Hee Univ, Inst Life Sci & Resources, Yongin 446701, South Korea

[3] Ildong Pharmaceut Co Ltd, Res Labs, Hwaseong 445170, South Korea

来源：

JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY | 2010年 / 53卷 / 03期

关键词：

(8E)-ligstroside; beta-secretase; Osmanthus fragrans; secoiridoid; ALZHEIMERS-DISEASE;

D O I：

10.3839/jksabc.2010.057

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

One secoiridoid glycoside was isolated from the EtOAc-soluble fraction of flowers of Osmanthus fragrans var. aurantiacus by repeated silica gel, octadecyl silica gel (ODS) and Sephadex LH-20 column chromatographies. It was identified as (8E)-ligstroside based on spectroscopic methods including NMR and MS. This compound has been first isolated from Osmanthus fragrans var. aurantiacus, and showed BACE1 inhibition activity.

引用

页码：371 / 374

页数：4

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