Novel Biginelli-like three-component cyclocondensation reaction:: efficient synthesis of 5-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones

被引：105

作者：

Wang, ZT

Xu, LW

Xia, CG

Wang, HQ ^{[1
]}

机构：

[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

[2] Univ Petr E China, Dept Applicat Chem, Shandong 257062, Peoples R China

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 42期

关键词：

three component; Biginelli-like reaction; cyclocondensation; one pot; iron;

D O I：

10.1016/j.tetlet.2004.08.107

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Iron (III) catalyzed the three-component Biginelli-like cyclocondensation reaction efficiently in acetonitrile to afford the corresponding 5-unsubstituted 3,4-dihydropyrimidin-2-(1H)-ones in high yields. The first Biginelli-like reactions of urea, aldehydes and ketones were furnished important new 3,4-dihydropyrimidin-2-(1H)-ones derivatives suitable for further study. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：7951 / 7953

页数：3

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