Are tumor-infiltrating lymphocytes protagonists or background actors in patient selection for cancer immunotherapy?

被引：61

作者：

Zito Marino, Federica ^{[1
,2
]}

Ascierto, Paolo Antonio ^{[3
]}

Rossi, Giulio ^{[4
]}

Staibano, Stefania ^{[5
]}

Montella, Marco ^{[2
]}

Russo, Daniela ^{[5
]}

Alfano, Roberto ^{[6
]}

Morabito, Alessandro ^{[7
]}

Botti, Gerardo ^{[1
]}

Franco, Renato ^{[2
]}

机构：

[1] IRCCS, Ist Nazl Tumori, Pathol Unit, Fdn G Pascale, Naples, Italy

[2] Univ Campania Luigi Vanvitelli, Pathol Unit, Naples, Italy

[3] Canc Immunotherapy & Innovat Therapy IRCCS, Unit Melanoma, Naples, Italy

[4] Azienda USL Valle Aosta, Unit Pathol Anat, Aosta, Italy

[5] Univ Naples Federico II, Dept Biomorphol & Funct Sci, Naples, Italy

[6] Univ Campania Luigi Vanvitelli, Dept Anesthesiol Surg & Emergency, Naples, Italy

[7] IRCCS, Ist Nazl Tumori, Dept Thorac Surg & Med Oncol, Med Oncol Unit,Fdn G Pascale, Naples, Italy

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2017年 / 17卷 / 06期

关键词：

Immunotherapy; immune checkpoint inhibitors; microenvironment; multiplex immunohistochemical; programmed death 1; Tumor-infiltrating lymphocytes; CD8(+) T-LYMPHOCYTES; PROGNOSTIC-SIGNIFICANCE; CHECKPOINT BLOCKADE; PD-1; BLOCKADE; BREAST-CANCER; PREDICT RESPONSE; MELANOMA; CELLS; EXPRESSION; SURVIVAL;

D O I：

10.1080/14712598.2017.1309387

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Introduction: Tumor-infiltrating lymphocytes (TILs) are frequently observed in several tumors, reflecting the dynamic process of ''' cancer immunoediting '''. Prognostic and predictive values of TILs have been demonstrated in different cancers, proving their pivotal role in clinical outcome. In recent years, new therapies targeting immune checkpoint inhibitors, especially CTLA-4 and PD-1/PDL-1 pathways, have been introduced into clinical practice. In this context, TILs may even have a possible utility as a predictive biomarker for immunotherapy response. Areas covered: In this review, the authors summarize the most relevant knowledge related to TILs. This includes their prognostic and predictive significance in various types of tumour and the recent findings about their potential role in the cancer immunotherapy. Expert opinion: TILs evaluation could lead to a predictive biomarker for immunotherapy effectiveness in several cancer types. Furthermore, typing of TILs subpopulation could have clinical relevance in patient selection for treatment with immune checkpoint inhibitors. However further studies are still needed.

引用

页码：735 / 746

页数：12

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