Humoral Response in Hemodialysis Patients Following COVID-19 Vaccination and Breakthrough Infections during Delta and Omicron Variant Predominance

被引:12
作者
Chinnadurai, Rajkumar [1 ,2 ]
Wu, Henry H. L. [2 ,3 ]
Cox, Eleanor [1 ]
Moore, Jayne [1 ]
Clough, Toni [1 ]
Lamerton, Elizabeth [1 ]
Donne, Rosie [1 ]
O'Riordan, Edmond [1 ]
Poulikakos, Dimitrios [1 ,2 ]
机构
[1] Northern Care Alliance NHS Fdn Trust, Dept Renal Med, Salford M6 8HD, Lancs, England
[2] Univ Manchester, Fac Biol Med & Hlth, Manchester M13 9PL, Lancs, England
[3] Lancashire Teaching Hosp NHS Fdn Trust, Dept Renal Med, Preston PR2 9HT, Lancs, England
关键词
COVID-19; vaccination; humoral response; hemodialysis; breakthrough infections; Delta variant; Omicron variant; HEPATITIS-B VACCINE; ANTIBODY-RESPONSE;
D O I
10.3390/vaccines10040498
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: The advancement of COVID-19 vaccination programs globally has been viewed as an integral strategy to reduce both the number of COVID-19 cases and consequential complications of COVID-19, particularly for high-risk patient groups. There are limited data on the antibody response and protection from disease infection and severity in patients requiring hemodialysis (HD) following COVID-19 vaccination during the Delta and Omicron variant predominance. We conducted a study aiming to evaluate humoral immunity derived from two different COVID-19 vaccines administered to our in-centre HD population and investigated the characteristics of breakthrough COVID-19 infections occurring post-vaccination within this population. Methods: This is a prospective observational study including patients receiving HD at Salford Royal Hospital. The first and second doses of COVID-19 vaccinations (Pfizer BioNTech BNT162b2 or Oxford AstraZeneca ChAdOx1 nCoV-19) were administered to this patient cohort since January 2021. The incidence of any breakthrough COVID-19 infections occurring in double vaccinated patients between 1 April 2021 and 15 January 2022 was recorded. Patients were screened weekly with nasal and pharyngeal nasopharyngeal swabs for real-time Reverse Transcription Polymerase Chain Reaction (rRT-PCR) for COVID-19, whilst SARS-CoV-2 antibody testing was performed alongside monthly routine HD bloods. Results: Four hundred eleven patients receiving HD were included in this study, of which 170 of 178 patients (95.5%) with available data on antibody status following two doses of the Pfizer BioNTech BNT162b2 vaccination had detectable antibody response, whilst this was the case for 97 of 101 patients (96.1%) who received two doses of the Oxford AstraZeneca ChAdOx1 nCoV-19 vaccine. For 12 seronegative patients who received a booster vaccine (third dose), nine seroconverted, while one remained negative and two were not tested. No statistically significant differences were observed with regards to antibody status between those receiving Pfizer BioNTech BNT162b2 and Oxford AstraZeneca ChAdOx1 nCoV-19 vaccines. Sixty-three of 353 patients with two doses of COVID-19 vaccination had breakthrough COVID-19 infection (40 during Delta and 23 during Omicron variant predominance). Of the 40 patients during the delta period, five were admitted into hospital and there were two reported deaths due to COVID-19-related illness. There were no COVID-19 associated hospitalizations or deaths during the Omicron variant predominance. Conclusions: The vast majority of HD patients who received two doses of the Pfizer BioNTech BNT162b2 or Oxford AstraZeneca ChAdOx1 nCoV-19 vaccinations developed detectable antibody responses. Our results support the value of booster vaccination with mRNA-based COVID-19 vaccine in HD patients and highlight the need for ongoing surveillance programmes with rRT-PCR and antibody testing for timely detection of positive cases.
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页数:12
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共 21 条
[1]   COVID-19 hospital admissions and deaths after BNT162b2 and ChAdOx1 nCoV-19 vaccinations in 2middot57 million people in Scotland (EAVE II): a prospective cohort study [J].
Agrawal, Utkarsh ;
Katikireddi, Srinivasa Vittal ;
McCowan, Colin ;
Mulholland, Rachel H. ;
Azcoaga-Lorenzo, Amaya ;
Amele, Sarah ;
Fagbamigbe, Adeniyi Francis ;
Vasileiou, Eleftheria ;
Grange, Zoe ;
Shi, Ting ;
Kerr, Steven ;
Moore, Emily ;
Murray, Josephine L. K. ;
Shah, Syed Ahmar ;
Ritchie, Lewis ;
O'Reilly, Dermot ;
Stock, Sarah J. ;
Beggs, Jillian ;
Chuter, Antony ;
Torabi, Fatemah ;
Akbari, Ashley ;
Bedston, Stuart ;
McMenamin, Jim ;
Wood, Rachael ;
Tang, Ruby S. M. ;
de Lusignan, Simon ;
Hobbs, F. D. Richard ;
Woolhouse, Mark ;
Simpson, Colin R. ;
Robertson, Chris ;
Sheikh, Aziz .
LANCET RESPIRATORY MEDICINE, 2020, 9 (12) :1439-1449
[2]   SARS-CoV-2 Vaccine Antibody Response and Breakthrough Infection in Patients Receiving Dialysis [J].
Anand, Shuchi ;
Montez-Rath, Maria E. ;
Han, Jialin ;
Garcia, Pablo ;
Cadden, LinaCel ;
Hunsader, Patti ;
Morgan, Curt ;
Kerschmann, Russell ;
Beyer, Paul ;
Dittrich, Mary ;
Block, Geoffrey A. ;
Chertow, Glenn M. ;
Parsonnet, Julie .
ANNALS OF INTERNAL MEDICINE, 2022, 175 (03) :371-+
[3]   Influenza A/H1N1 Vaccine in Patients Treated by Kidney Transplant or Dialysis: A Cohort Study [J].
Broeders, Nilufer E. ;
Hombrouck, Anneleen ;
Lemy, Anne ;
Wissing, Karl Martin ;
Racape, Judith ;
Gastaldello, Karine ;
Massart, Annick ;
Van Gucht, Steven ;
Weichselbaum, Laura ;
De Mul, Aurelie ;
Brochier, Bernard ;
Thomas, Isabelle ;
Abramowicz, Daniel .
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2011, 6 (11) :2573-2578
[4]   The COVID-19 pandemic: consequences for nephrology [J].
Bruchfeld, Annette .
NATURE REVIEWS NEPHROLOGY, 2021, 17 (02) :81-82
[5]   LONG-TERM IMMUNOGENICITY AND EFFICACY OF HEPATITIS-B VACCINE IN HEMODIALYSIS-PATIENTS [J].
BUTI, M ;
VILADOMIU, L ;
JARDI, R ;
OLMOS, A ;
RODRIGUEZ, JA ;
BARTOLOME, J ;
ESTEBAN, R ;
GUARDIA, J .
AMERICAN JOURNAL OF NEPHROLOGY, 1992, 12 (03) :144-147
[6]   Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients [J].
Carr, Edward J. ;
Wu, Mary ;
Harvey, Ruth ;
Wall, Emma C. ;
Kelly, Gavin ;
Hussain, Saira ;
Howell, Michael ;
Kassiotis, George ;
Swanton, Charles ;
Gandhi, Sonia ;
Bauer, David L. V. ;
Billany, Roseanne E. ;
Graham-Brown, Matthew P. M. ;
Beckett, Joseph ;
Bull, Katherine ;
Shankar, Sushma ;
Henderson, Scott ;
Motallebzadeh, Reza ;
Salama, Alan D. ;
Harper, Lorraine ;
Mark, Patrick B. ;
McAdoo, Stephen ;
Willicombe, Michelle ;
Beale, Rupert .
LANCET, 2021, 398 (10305) :1038-1041
[7]   COVID-19 outcomes in patients waitlisted for kidney transplantation and kidney transplant recipients [J].
Craig-Schapiro, Rebecca ;
Salinas, Thalia ;
Lubetzky, Michelle ;
Abel, Brittany T. ;
Sultan, Samuel ;
Lee, John R. ;
Kapur, Sandip ;
Aull, Meredith J. ;
Dadhania, Darshana M. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2021, 21 (04) :1576-1585
[8]   Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2 A Prospective Cohort Study [J].
Deepak, Parakkal ;
Kim, Wooseob ;
Paley, Michael A. ;
Yang, Monica ;
Carvidi, Alexander B. ;
Demissie, Emanuel G. ;
El-Qunni, Alia A. ;
Haile, Alem ;
Huang, Katherine ;
Kinnett, Baylee ;
Liebeskind, Mariel J. ;
Liu, Zhuoming ;
McMorrow, Lily E. ;
Paez, Diana ;
Pawar, Niti ;
Perantie, Dana C. ;
Schriefer, Rebecca E. ;
Sides, Shannon E. ;
Thapa, Mahima ;
Gergely, Mate ;
Abushamma, Suha ;
Akuse, Sewuese ;
Klebert, Michael ;
Mitchell, Lynne ;
Nix, Darren ;
Graf, Jonathan ;
Taylor, Kimberly E. ;
Chahin, Salim ;
Ciorba, Matthew A. ;
Katz, Patricia ;
Matloubian, Mehrdad ;
O'Halloran, Jane A. ;
Presti, Rachel M. ;
Wu, Gregory F. ;
Whelan, Sean P. J. ;
Buchser, William J. ;
Gensler, Lianne S. ;
Nakamura, Mary C. ;
Ellebedy, Ali H. ;
Kim, Alfred H. J. .
ANNALS OF INTERNAL MEDICINE, 2021, 174 (11) :1572-+
[9]   Long-term Antibody Response to the BNT162b2 Vaccine Among Maintenance Hemodialysis Patients [J].
Nacasch, Naomi ;
Erez, Daniel ;
Lishner, Michael ;
Benchetrit, Sydney ;
Rozenberg, Ilan ;
Sarel, Erez ;
Shitrit, Pnina ;
Wand, Ori ;
Cohen-Hagai, Keren .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2022, 79 (01) :137-139
[10]   Omicron severity: milder but not mild Comment [J].
Nealon, Joshua ;
Cowling, Benjamin J. .
LANCET, 2022, 399 (10323) :412-413