An antimalarial drug, tafenoquine, as a fluorescent receptor for ratiometric detection of hypochlorite

被引：10

作者：

Das, Avijit Kumar ^{[1
]}

Hayashi, Naoto ^{[1
]}

Shiraishi, Yasuhiro ^{[1
,2
]}

Hirai, Takayuki ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Engn Sci, Div Chem Engn, Res Ctr Solar Energy Chem, Toyonaka, Osaka 5608531, Japan

[2] Japan Sci & Technol Agcy JST, Precursory Res Embryon Sci & Technol PRESTO, Saitama 3320012, Japan

来源：

RSC ADVANCES | 2017年 / 7卷 / 48期

基金：

日本科学技术振兴机构;

关键词：

IN-VIVO; AQUEOUS-MEDIA; LIVE CELLS; TURN-ON; PROBE; ACID; MYELOPEROXIDASE; MOLECULES; OXYGEN; SENSOR;

D O I：

10.1039/c7ra04867j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tafenoquine (TQ), a fluorescent antimalarial drug, was used as a receptor for the fluorometric detection of hypochlorite (OCl-). TQ itself exhibits a strong fluorescence at 476 nm, but OCl(-)selective cyclization of its pentan-1,4-diamine moiety creates a blue-shifted fluorescence at 361 nm. This ratiometric response facilitates rapid, selective, and sensitive detection of OCl- in aqueous media with physiological pH. This response is also applicable to a simple test kit analysis and allows fluorometric OCl- imaging in living cells.

引用

收藏

页码：30453 / 30458

页数：6

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