Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies

被引：395
作者：
Hemmann, Stefanie
Graf, Juergen
Roderfeld, Martin
Roeb, Elke
机构：
[1] Univ Hosp Giessen & Marburg GmbH, Dept Med 2, D-35392 Giessen, Germany
[2] Univ Hosp Giessen & Marburg GmbH, Dept Anaesthesiol & Intens Care, D-35033 Marburg, Germany
来源：
JOURNAL OF HEPATOLOGY | 2007年 / 46卷 / 05期
关键词：
liver; fibrosis; MMP; TIMP; matrix; metalloproteinase; tissue; inhibitor; therapy; expression;
D O I：
10.1016/j.jhep.2007.02.003
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
In liver tissue matrix metalloproteinases (MMPs) and their specific inhibitors (tissue inhibitors of metalloproteinases, TIMPs) play a pivotal role in both, fibrogenesis and fibrolysis. The current knowledge of the pathophysiology of liver fibrogenesis with special emphasis on MMPs and TIMPs is presented. A systematic literature search was conducted. All experimental models of liver fibrosis that evaluated a defined anti-fibrotic intervention in vivo or in vitro considering MMPs and TIMPs were selected. The methodological quality of all these publications has been critically appraised using an objective scoring system and the content has been summarized in a table. (C) 2007 European Association for the Study of the Liver. Published by Elsevier BN. All rights reserved.
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页码：955 / 975
页数：21
相关论文
共 186 条
  • [1] MATRIX METALLOPROTEINASE-2 IS AN INTERSTITIAL COLLAGENASE - INHIBITOR-FREE ENZYME CATALYZES THE CLEAVAGE OF COLLAGEN FIBRILS AND SOLUBLE NATIVE TYPE-I COLLAGEN GENERATING THE SPECIFIC 3/4-LENGTH AND 1/4-LENGTH FRAGMENTS
    AIMES, RT
    QUIGLEY, JP
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (11) : 5872 - 5876
  • [2] Statistically significant
    不详
    [J]. NATURE MEDICINE, 2005, 11 (01) : 1 - 1
  • [3] The matrix metalloproteinase-14 (MMP-14) gene is structurally distinct from other MMP genes and is co-expressed with the TIMP-2 gene during mouse embryogenesis
    Apte, SS
    Fukai, N
    Beier, DR
    Olsen, BR
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (41) : 25511 - 25517
  • [4] Enhanced matrix degradation after withdrawal of TGF-β1 triggers hepatocytes from apoptosis to proliferation and regeneration
    Arendt, E
    Ueberham, U
    Bittner, R
    Gebhardt, R
    Ueberham, E
    [J]. CELL PROLIFERATION, 2005, 38 (05) : 287 - 299
  • [5] Arthur MJP, 2000, AM J PHYSIOL-GASTR L, V279, pG245
  • [6] Improving the quality of reporting of randomized controlled trials - The CONSORT statement
    Begg, C
    Cho, M
    Eastwood, S
    Horton, R
    Moher, D
    Olkin, I
    Pitkin, R
    Rennie, D
    Schulz, KF
    Simel, D
    Stroup, DF
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 276 (08): : 637 - 639
  • [7] Inhibition of markers of hepatic stellate cell activation by the hormone relaxin
    Bennett, RG
    Kharbanda, KK
    Tuma, DJ
    [J]. BIOCHEMICAL PHARMACOLOGY, 2003, 66 (05) : 867 - 874
  • [8] Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver
    Benyon, RC
    Iredale, JP
    Goddard, S
    Winwood, PJ
    Arthur, MJP
    [J]. GASTROENTEROLOGY, 1996, 110 (03) : 821 - 831
  • [9] Extracellular matrix degradation and the role of hepatic stellate cells
    Benyon, RC
    Arthur, MJP
    [J]. SEMINARS IN LIVER DISEASE, 2001, 21 (03) : 373 - 384
  • [10] Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation
    Benyon, RC
    Hovell, CJ
    Da Gaça, M
    Jones, EH
    Iredale, JP
    Arthur, MJP
    [J]. HEPATOLOGY, 1999, 30 (04) : 977 - 986
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