Two decades of advances in diterpenoid alkaloids with cytotoxicity activities

被引：21
|
作者：
Liang, Xiaoxia [1 ]
Gao, Yingying [1 ]
Luan, Shangxian [1 ]
机构：
[1] Sichuan Agr Univ, Coll Vet Med, Nat Med Res Ctr, Chengdu 611130, Sichuan, Peoples R China
来源：
RSC ADVANCES | 2018年 / 8卷 / 42期
基金：
中国国家自然科学基金;
关键词：
DERIVATIVES; GEMCITABINE; RADIOSENSITIZATION; APOPTOSIS; MECHANISM;
D O I：
10.1039/c8ra03911a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The important pharmacological activities and structural complexity of diterpenoid alkaloids have long stimulated strong scientific interest; some of these naturally abundant compounds have been reported to be highly promising for treating cancer. From 2008 to 2018, the cytotoxicity activities of more than 250 diterpenoid alkaloids were tested against several cancer cell lines. This review focuses on the progress of diterpenoid alkaloids with different structures derived from Ranunculaceae plants and some of their derivatives with potential anticancer activities. Then, we discuss the application prospects and development of active diterpenoid alkaloids.
引用
收藏
页码：23937 / 23946
页数：10
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