Rituximab use for refractory anti-HMGCR immune-mediated necrotizing myopathy: A case report

被引：6

作者：

Gupta, Sonia ^{[1
]}

Rakhra, Amandeep ^{[2
]}

Thallapally, Vinay ^{[1
]}

Nahas, Joseph ^{[1
]}

机构：

[1] Creighton Univ, Dept Internal Med, 7710 Mercy Rd 3000, Omaha, NE 68124 USA

[2] Dartmouth Hitchcock Med Ctr, Dept Rheumatol, Lebanon, NH 03766 USA

来源：

INTRACTABLE & RARE DISEASES RESEARCH | 2021年 / 10卷 / 02期

关键词：

anti-HMGCR; immune-mediated necrotizing myopathy; immunosuppressants; rituximab; STATIN-INDUCED MYOPATHY; AUTOIMMUNE MYOPATHY; MYOSITIS;

D O I：

10.5582/irdr.2020.03144

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immunosuppression is the cornerstone therapy for anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) myopathy. Typical immunosuppressants such as corticosteroids. methotrexate. and azathioprine have been used in conjunction with removal of the offending agent. yet the use of rituximab is more limited in this type of myopathy. Reported here is a case of a patient who responded well to rituximab (RTX) after the standard immunosuppressants had failed. This case illustrates the importance of further studies to evaluate the role of RTX in anti-HMGCR myopathy.

引用

页码：122 / 125

页数：4

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