Synthesis of PVP-coated ultra-small Fe3O4 nanoparticles as a MRI contrast agent

被引：97

作者：

Zhang, Ying ^{[1
,2
,3
]}

Liu, Jing-Ying ^{[3
]}

Ma, Song ^{[1
,2
]}

Zhang, Ya-Jing ^{[1
,2
]}

Zhao, Xiang ^{[3
]}

Zhang, Xiang-Dong ^{[1
,2
,4
]}

Zhang, Zhi-Dong ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang 110016, Peoples R China

[2] Chinese Acad Sci, Int Ctr Mat Phys, Shenyang 110016, Peoples R China

[3] Shen Yang Pharmaceut Univ, Coll Pharmaceut Engn, Shenyang 110016, Peoples R China

[4] Liaoning Univ, Coll Chem Sci & Engn, Shenyang 110036, Peoples R China

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2010年 / 21卷 / 04期

基金：

中国国家自然科学基金;

关键词：

IRON-OXIDE NANOPARTICLES; SIZE-CONTROLLED SYNTHESIS; MAGNETITE NANOPARTICLES; W/O MICROEMULSION;

D O I：

10.1007/s10856-009-3881-3

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Ultra-small Fe3O4 nanoparticles were prepared by using the coprecipitation method, in which the polyvinylpyrrolidone (PVP) serves as a stabilizer. The nanoparticles were characterized by means of X-ray diffraction (XRD), transmission electron microscopy (TEM), infra spectrum (IR), X-ray photoelectron spectroscopy (XPS) and in vivo magnetic resonance imaging (MRI) test. The results showed that the particles' size was determined by the dripping rate and that PVP molecules played the role of preventing the aggregation and restricting the size of Fe3O4 nanoparticles. The Fe3O4 nanoparticles with diameter from 6.5 to 1.9 nm obviously exhibited negative contrast enhancement and concentrated at the target area guided by a permanent magnet.

引用

页码：1205 / 1210

页数：6

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