Orexins/hypocretins and aminergic systems

被引：31
作者：
Eriksson, K. S. [1 ]
Sergeeva, O. A. [1 ]
Haas, H. L. [1 ]
Selbach, O. [1 ]
机构：
[1] Univ Dusseldorf, Dept Neurophysiol, D-40001 Dusseldorf, Germany
来源：
ACTA PHYSIOLOGICA | 2010年 / 198卷 / 03期
关键词：
acetylcholine; dopamine; histamine; hypocretin; noradrenaline; serotonin; THYROTROPIN-RELEASING-HORMONE; LONG-TERM POTENTIATION; OREXIN-A HYPOCRETIN-1; HISTAMINERGIC NEURONS; LOCUS-COERULEUS; SYNAPTIC PLASTICITY; BRAIN HISTAMINE; OREXIN/HYPOCRETIN NEURONS; TUBEROMAMMILLARY NUCLEUS; HYPOTHALAMIC PEPTIDES;
D O I：
10.1111/j.1748-1716.2009.02015.x
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Orexin/hypocretin neurones in the posterior hypothalamus are mutually connected with noradrenergic, serotonergic, dopaminergic, histaminergic, and cholinergic neurone systems. They activate these targets by direct post-synaptic and indirect pre-synaptic mechanisms and in turn receive inhibitory feedback and excitatory feed forward control. With respect to behavioural state control, orexin/hypocretin neurones are conducting the orchestra of biogenic amines. This review highlights the role of these players in the control of energy administration, sleep-wake architecture, cortical activation, plasticity, and memory functions in health and disease.
引用
收藏
页码：263 / 275
页数：13
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