Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo

被引：142
作者：
Iranshahi, M. [1 ]
Sahebkar, A. [1 ]
Hosseini, S. T. [1 ]
Takasaki, M. [2 ]
Konoshima, T. [2 ]
Tokuda, H. [3 ]
机构：
[1] Mashhad Univ Med Sci, Sch Pharm, Biotechnol Res Ctr, Dept Pharmacognosy, Mashhad, Iran
[2] Chiba Inst Sci, Dept Pharmacol, Chiba, Japan
[3] Kyoto Prefectural Univ Med, Dept Mol Biochem, Kamigyo Ku, Kyoto 6020841, Japan
来源：
PHYTOMEDICINE | 2010年 / 17卷 / 3-4期
关键词：
Ferula diversivittata; Diversin; EBV-EA activation; Two-stage mouse skin carcinogenesis; Curcumin; BARR-VIRUS ACTIVATION; MOUSE SKIN CARCINOGENESIS; TUMOR-PROMOTING ACTIVITY; SERRATANE-TYPE TRITERPENOIDS; PROTEIN-KINASE-C; SESQUITERPENE COUMARINS; MELANOMA-CELLS; STEM BARK; 12-O-TETRADECANOYLPHORBOL-13-ACETATE; INHIBITORS;
D O I：
10.1016/j.phymed.2009.05.020
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A prenylated coumarin (diversin, 1) together with four new sesquiterpene lactones (diversolides A, D, F and G, 2-5) isolated from the roots of Ferula diversivittata were studied for their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). All of the tested compounds were active against EBV-EA activation. Among these compounds diversin (IC(50): 7.7) exhibited the strongest inhibitory effect and was selected to examine its effects on in vivo two-stage mouse skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) as initiator and TPA as promoter. Treatment with compound 1 (85 nmol) along with DMBA/TPA inhibited papilloma formation up to week 7 and the percentage of papilloma bearers was approximately 93.3% at week 20. The average number of papillomas formed per mouse was only 5.5 even at week 20. The results of the present investigation indicated that diversin might be valuable as a potent cancer chemopreventive agent and its potency was comparable with those of curcumin and quercetin, two well-known cancer chemopreventive agents. (C) 2009 Elsevier GmbH. All rights reserved.
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页码：269 / 273
页数：5
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