Cognitive and Electrophysiological Correlates of Working Memory Impairments in Neurofibromatosis Type 1

被引：20

作者：

Pobric, Gorana ^{[1
]}

Taylor, Jason R. ^{[1
]}

Ramalingam, Hemavathy M. ^{[2
]}

Pye, Emily ^{[1
]}

Robinson, Louise ^{[2
]}

Vassallo, Grace ^{[3
]}

Jung, JeYoung ^{[4
]}

Bhandary, Misty ^{[2
]}

Szumanska-Ryt, Karolina ^{[2
]}

Theodosiou, Louise ^{[2
]}

Evans, D. Gareth ^{[3
,5
]}

Eelloo, Judith ^{[3
]}

Burkitt-Wright, Emma ^{[3
]}

Hulleman, Johan ^{[1
]}

Green, Jonathan ^{[1
,2
]}

Garg, Shruti ^{[1
,2
]}

机构：

[1] Univ Manchester, Sch Biol Sci, Div Neurosci & Expt Psychol, Fac Biol Med & Hlth, Room 3-310,Jean McFarlane Bldg,Oxford Rd, Manchester M13 9WL, Lancs, England

[2] Royal Manchester Childrens Hosp, Manchester Acad Hlth Sci Ctr, Cent Manchester Univ Hosp NHS Fdn Trust, Child & Adolescent Mental Hlth Serv, Manchester, Lancs, England

[3] Manchester Acad Hlth Sci Ctr, Cent Manchester Univ Hosp NHS Fdn Trust, NF1 Serv, Nationally Commissioned Complex, Manchester, Lancs, England

[4] Univ Nottingham, Sch Psychol, Precis Imaging Beacon, Nottingham, England

[5] Univ Manchester, Div Evolut & Genom Sci, Manchester Ctr Genom Med Med & Hlth, Fac Biol,North West Genom Hub, Manchester, Lancs, England

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2022年 / 52卷 / 04期

关键词：

Neurofibromatosis; 1; Working memory; N-back task; EEG; P300; EXECUTIVE FUNCTION; CHILDREN; ATTENTION; ADHD; P300; MATURATION; NETWORKS; DYNAMICS; LANGUAGE; DEFICIT;

D O I：

10.1007/s10803-021-05043-3

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Neurofibromatosis 1 (NF1) is a single gene disorder associated with working Memory (WM) impairments. The aim of this study was to investigate P300 event-related potential (ERP) associated with WM in NF1. Sixteen adolescents with NF1 were compared with controls on measures of WM and EEG was recorded during a WM nback task. The NF1 group showed poorer performance on measures of WM as compared to the control group. No group differences were observed in P300 amplitude at Pz, but P300 latency was shorter in the NF1 group. Topographic analyses of P300 amplitude showed group differences indicating neural processing differences in the NF1 group relative to controls, which possibly contribute to the cognitive deficits seen in this population.

引用

页码：1478 / 1494

页数：17

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