Detecting Epistatic Interactions in Metagenome-Wide Association Studies by metaBOOST

被引：2

作者：

Wu, Mengmeng

Jiang, Rui ^{[1
]}

机构：

[1] Tsinghua Univ, Bioinformat Div, MOE Key Lab Bioinformat, Beijing 100084, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

GUT MICROBIOME; OBESITY; HEALTH;

D O I：

10.1155/2014/398147

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Material and Methods. We recall the definition of epistasis and extend it for metagenomic biomarkers and then we describe the overview of our method metaBOOST and provide detailed information about each step of metaBOOST. Results. We describe the data sources for both simulation studies and real metagenomic datasets. Then, we describe the procedure of simulation studies and provide results for it. After that, we conduct real datasets studies and report the results. Conclusions and Discussion. Finally, we conclude our method and discuss some possible improvements for the future.

引用

页数：12

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