Rodent Models to Analyze the Glioma Microenvironment

被引：11
|
作者：
Hetze, Susann [1 ,2 ]
Sure, Ulrich [1 ]
Schedlowski, Manfred [2 ,3 ]
Hadamitzky, Martin [2 ]
Barthel, Lennart [1 ,2 ]
机构：
[1] Univ Hosp Essen, Dept Neurosurg, Hufelandstr 55, D-45147 Essen, Germany
[2] Univ Hosp Essen, Inst Med Psychol & Behav Immunobiol, Essen, Germany
[3] Karolinska Inst, Dept Clin Neurosci, Osher Ctr Integrat Med, Stockholm, Sweden
来源：
ASN NEURO | 2021年 / 13卷
关键词：
tumor microenvironment; glioma; rodent model; brain tumor; synthetic biology; preclinical oncology; IN-VIVO MODELS; MOUSE MODELS; STEM-CELLS; BRAIN-TUMORS; XENOGRAFT MODEL; GLIOBLASTOMA; CANCER; MICE; ASSOCIATION; METABOLISM;
D O I：
10.1177/17590914211005074
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Animal models are still indispensable for understanding the basic principles of glioma development and invasion. Preclinical approaches aim to analyze the treatment efficacy of new drugs before translation into clinical trials is possible. Various animal disease models are available, but not every approach is useful for addressing specific questions. In recent years, it has become increasingly evident that the tumor microenvironment plays a key role in the nature of glioma. In addition to providing an overview, this review evaluates available rodent models in terms of usability for research on the glioma microenvironment.
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收藏
页数：12
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