Expression of epidermal growth factor receptor in carcinoma of the cervix

被引:82
作者
Kim, JW [1 ]
Kim, YT [1 ]
Kim, DK [1 ]
Song, CH [1 ]
Lee, JW [1 ]
机构
[1] YONSEI UNIV,COLL MED,DEPT CLIN PATHOL,SEOUL 120752,SOUTH KOREA
关键词
D O I
10.1006/gyno.1996.0039
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Increased expression of the epidermal growth factor receptor (EGFR) gene has been shown in a large number of tumors, generally indicating a more aggressive biological behavior of cancers than those with low or normal expression. The role of EGFR in the tumorigenesis of the uterine cervix has been poorly understood and controversial. In order to explore the relationship between EGFR status and cervical carcinoma, tissues were analyzed from 40 patients, each of whom had invasive cervical carcinoma prior to treatment, 20 patients with cervical intraepithelial neoplasia (GIN) and 10 control cases who underwent hysterectomy due to benign gynecological disease at Yonsei University College of Medicine. We measured EGFR with an enzyme-linked immunosorbent assay which was a sandwich type using a mouse monoclonal capture antibody and a rabbit antiserum as detector. Patients with invasive cervical cancer were found to have significantly higher median EGFR expression than either the patients with CIN (P = 0.002) or the control (P = 0.001), respectively. However, there was no significant difference in EGFR status between CIN and the control groups. Overexpression of EGFR was found in 29 of 40 (72.5%) invasive cervical cancers and in 5 of 20 (25%) CIN patients. In invasive cervical cancer, no significant difference in EGFR levels was noted when stratified according to age, menopausal status, histological cell type, or clinical stage. With regard to tumor size, lesions of 4 cm and larger had significantly higher receptor levels than those lesions under 4 cm (P = 0.003). Even though quantitative EGFR status did not correlate with other prognostic parameters except tumor size, our results were consistent with the concept that EGFR may play an important role in malignant transformation and tumorigenesis in cervical cancer. (C) 1996 Academic Press, Inc.
引用
收藏
页码:283 / 287
页数:5
相关论文
共 40 条
  • [31] SCHREIBER AB, 1983, J BIOL CHEM, V258, P846
  • [32] STRUCTURE AND FUNCTION OF HUMAN AMPHIREGULIN - A MEMBER OF THE EPIDERMAL GROWTH-FACTOR FAMILY
    SHOYAB, M
    PLOWMAN, GD
    MCDONALD, VL
    BRADLEY, JG
    TODARO, GJ
    [J]. SCIENCE, 1989, 243 (4894) : 1074 - 1076
  • [33] EGF BINDING IS QUANTITATIVELY RELATED TO GROWTH IN NODE-POSITIVE BREAST-CANCER
    SPITZER, E
    KOEPKE, K
    KUNDE, D
    GROSSE, R
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 1988, 12 (01) : 45 - 49
  • [34] STOSCHECK CM, 1986, CANCER RES, V46, P1030
  • [35] TOI M, 1990, CANCER, V65, P1980, DOI 10.1002/1097-0142(19900501)65:9<1980::AID-CNCR2820650917>3.0.CO
  • [36] 2-U
  • [37] MULTIPARAMETER FLOW-CYTOMETRIC QUANTITATION OF EPIDERMAL GROWTH-FACTOR RECEPTOR AND C-ERBB-2 ONCOPROTEIN IN NORMAL AND NEOPLASTIC TISSUES OF THE FEMALE GENITAL-TRACT
    VANDAM, PA
    LOWE, DG
    WATSON, JV
    JAMES, M
    CHARD, T
    HUDSON, CN
    SHEPHERD, JH
    [J]. GYNECOLOGIC ONCOLOGY, 1991, 42 (03) : 256 - 264
  • [38] A MONOCLONAL-ANTIBODY TO THE HUMAN EPIDERMAL GROWTH-FACTOR RECEPTOR
    WATERFIELD, MD
    MAYES, ELV
    STROOBANT, P
    BENNET, PLP
    YOUNG, S
    GOODFELLOW, PN
    BANTING, GS
    OZANNE, B
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 1982, 20 (02) : 149 - 161
  • [39] SIMILARITY OF PROTEIN ENCODED BY THE HUMAN C-ERB-B-2 GENE TO EPIDERMAL GROWTH-FACTOR RECEPTOR
    YAMAMOTO, T
    IKAWA, S
    AKIYAMA, T
    SEMBA, K
    NOMURA, N
    MIYAJIMA, N
    SAITO, T
    TOYOSHIMA, K
    [J]. NATURE, 1986, 319 (6050) : 230 - 234
  • [40] GROWTH-FACTOR RECEPTOR TYROSINE KINASES
    YARDEN, Y
    ULLRICH, A
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1988, 57 : 443 - 478