Total synthesis of luotonin A and 14-substituted analogues

被引：36

作者：

Mason, Jeffrey J. ^{[1
]}

Bergman, Jan ^{[1
]}

机构：

[1] Karolinska Inst, Unit Organ Chem, Dept Biosci & Nutr, SE-14157 Huddinge, Sweden

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2007年 / 5卷 / 15期

关键词：

RADICAL CYCLIZATION; FACILE SYNTHESIS; QUINAZOLINE; QUINOLINE; ALKALOIDS; DNA; CAMPTOTHECIN; ACID;

D O I：

10.1039/b707684c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and concise synthesis of luotonin A was achieved from the previously described compounds ethyl 4-oxo-3,4-dihydroquinazoline-2-carboxylate and 1-(2-nitrophenyl)prop-2-en-1-one. New 14-substituted luotonin A analogues were prepared using 14-chloroluotonin A as the key intermediate.

引用

页码：2486 / 2490

页数：5

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