Identification of fetal growth-related single nucleotide polymorphisms in insulin-like growth factor (IGF)2 and IGF2 receptor gene regions

被引：0

作者：

Kaku, K ^{[1
]}

Osada, H ^{[1
]}

Iitsuka, Y ^{[1
]}

Masuda, K ^{[1
]}

Seki, K ^{[1
]}

Sekiya, S ^{[1
]}

机构：

[1] Chiba Univ, Sch Med, Chiba Univ Hosp, Dept Obstet & Gynecol, Chiba, Japan

来源：

FAOPS 2004: PROCEEDINGS OF THE 13TH CONGRESS OF THE FEDERATION OF ASIA AND OCEANIA PERINATAL SOCIETIES FAOPS 2004 | 2004年

关键词：

D O I：

暂无

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Experimental studies have shown that insulin-like growth factor (IGF)2 enhances fetal growth, whereas its receptor (IGF2R) is assumed to be suppressive. In this study, we tried to identify two types of single-nucleotide polymorphisms (SNPs) within the IGF2 gene (+3123 ApaI and +3580 MspI), and three types of SNPs within the exon of the IGF2R gene (+901C > G, +5002A > G and +6206A > G), which are related to birth weight. For +3123 ApaI polymorphism of the IGF2 gene, the birth weight SDUs according to neonate's genotype showed significant differences between the -/-, +/-, and +/+ groups. For +901C > G polymorphism of the IGF2R gene, when the alleles were classified by parental origin, a significant difference in birth weight SDU was found between the maternally derived C and G alleles. Therefore we succeeded to identify SNPs that are related to fetal growth in both gene regions.

引用

页码：143 / 147

页数：5

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