Montmorillonite-KSF mediated one step synthesis of pyranochromene derivatives

被引：3

作者：

Subbareddy, Chitreddy V. ^{[1
]}

Subashini, Radhakrishnan ^{[2
]}

Sumathi, Shanmugam ^{[1
]}

机构：

[1] VTT, Dept Chem, Vellore 632014, Tamil Nadu, India

[2] Arignar Anna Govt Arts Coll Women, Dept Chem, Vellore, Tamil Nadu, India

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2018年 / 1171卷

关键词：

Multicomponent reaction; Aromatic aldehydes; 4-Hydroxycoumarin; Montmorillonite KSF (MKSF); Pyrano[3,2-c]chromene; Heterogeneous catalyst; ANTIBACTERIAL AGENTS; ANTIOXIDANT ACTIVITY; 4H-CHROMENES; COUMARINS; PROTOCOL;

D O I：

10.1016/j.molstruc.2018.06.052

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

One-pot three-component reaction of substituted aromatic aldehydes, 2-cyanoacetamide and 4-hydroxycoumarin in the presence of Montmorillonite-KSF (MKSF) in ethanol results in the formation of pyrano[3,2-c]chromene-3-carboxylates (5a-m) has been described. The reaction was tested in different alcohols, afforded pyrano [3,2-c] chromene-3-carboxylates (5a-m) of the corresponding alcohols in good yield. The mechanism reveals that the alcohol (as solvent) plays a major role in the inter conversion of amide to the corresponding esters with Montmorillonite KSF (M-KSF) as a catalyst. Excellent yields, inexpensive and readily available substrates, environmentally benign reaction condition, shorter reaction time, and easy workup are the major advantageous features of this protocol. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：747 / 754

页数：8

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