Organocatalyzed conjugate umpolung of α,β-unsaturated aldehydes for the synthesis of γ-butyrolactones

被引：663

作者：

Burstein, C ^{[1
]}

Glorius, F ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim An Der Ruhr, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 45期

关键词：

aldehydes; carbene; heterocycles; organocatalysis; umpolung;

D O I：

10.1002/anie.200461572

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Advantage organocatalysis: N-heterocyclic carbenes can generate homoenolate equivalents under mild conditions by conjugate umpolung of α,β- unsaturated aldehydes. This organocatalytic reaction allows an efficient one-step synthesis of substituted γ-butyrolactones 1 (see scheme, Mes = mesityl).

引用

页码：6205 / 6208

页数：4

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