Organocatalyzed conjugate umpolung of α,β-unsaturated aldehydes for the synthesis of γ-butyrolactones

被引：663
作者：
Burstein, C [1 ]
Glorius, F [1 ]
机构：
[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim An Der Ruhr, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 45期
关键词：
aldehydes; carbene; heterocycles; organocatalysis; umpolung;
D O I：
10.1002/anie.200461572
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Advantage organocatalysis: N-heterocyclic carbenes can generate homoenolate equivalents under mild conditions by conjugate umpolung of α,β- unsaturated aldehydes. This organocatalytic reaction allows an efficient one-step synthesis of substituted γ-butyrolactones 1 (see scheme, Mes = mesityl).
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页码：6205 / 6208
页数：4
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