Mitochondrial Dynamics and Proteins Related to Neurodegenerative Diseases

被引：38

作者：

Alexiou, Athanasios ^{[1
]}

Nizami, Bilal ^{[2
]}

Khan, Faez Iqbal ^{[3
]}

Soursou, Georgia ^{[1
]}

Vairaktarakis, Charalampos ^{[4
]}

Chatzichronis, Stylianos ^{[1
]}

Tsiamis, Vasilis ^{[1
,5
]}

Manztavinos, Vasileios ^{[1
,4
]}

Yarla, Nagendra Sastry ^{[1
,6
]}

Ashraf, Ghulam Md ^{[7
]}

机构：

[1] Novel Global Community Educ Fdn, Herbersham, Australia

[2] Univ KwaZulu Natal, Sch Pharm & Pharmacol, ZA-4000 Durban, South Africa

[3] Rhodes Univ, Dept Chem, ZA-6139 Grahamstown, South Africa

[4] Univ Thessaly, Dept Comp Sci & Biomed Informat, Lamia 35100, Greece

[5] Univ Southern Denmark, Dept Math & Comp Sci, Odense, Denmark

[6] GITAM Univ, Inst Sci, Sch Life Sci, Dept Biochem & Bioinformat, Visakhapatnam, Andhra Prades, India

[7] King Abdulaziz Univ, King Fahd Med Res Ctr, POB 80216, Jeddah 21589, Saudi Arabia

来源：

CURRENT PROTEIN & PEPTIDE SCIENCE | 2018年 / 19卷 / 09期

关键词：

Proteins misfolding; mitochondrial dynamics; mitochondrial lesions; neurodegeneration; Alzheimer's disease; Parkinson's disease; Huntington's disease; CMT2A; reactive oxygen species; amyloid beta; tau; alpha-synuclein; parkin; PINK1; MFN1; MFN2; OPA1; DNM1L; ALPHA-SYNUCLEIN; ALZHEIMERS-DISEASE; EXTERNAL OPHTHALMOPLEGIA; FUSION; DNA; BRAIN; MUTATION; OPA1; TAU; PARKINSONISM;

D O I：

10.2174/1389203718666170810150151

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Disruptions in the regulation of mitochondrial dynamics and the occurrence of proteins misfolding lead to neuronal death, resulting in Age-related Dementia and Neurodegenerative diseases as well as Frailty. Functional, neurophysiologic and biochemical alterations within the mitochondrial populations can reveal deficits in brain energy metabolism resulting in Mild Cognitive Impairment, abnormal neural development, autonomic dysfunction and other mitochondrial disorders. Additionally, in cases of Alzheimer's disease or Parkinson's disease, a significant number of proteins seem to form unordered and problematic structures, leading through unknown mechanisms to pathological conditions. While the proteins structure prediction problem is still an open challenge regarding its complexity, several features associated with the correlations of misfolding proteins and Neurodegeneration are discussed in the present study and a computational analysis for the proteins Amyloid Beta, Tau, alpha-Synuclein, Parkin, Pink1, MFN1, MFN1, OPA1, and DNM1L is also presented.

引用

页码：850 / 857

页数：8

共 129 条

[11] NeuroMorpho.Org: A central resource for neuronal morphologies [J].

Ascoli, Giorgio A. ;

Donohue, Duncan E. ;

Halavi, Maryam .

JOURNAL OF NEUROSCIENCE, 2007, 27 (35) :9247-9251

[12] PERMANENT HUMAN PARKINSONISM DUE TO 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) - 7 CASES [J].

BALLARD, PA ;

TETRUD, JW ;

LANGSTON, JW .

NEUROLOGY, 1985, 35 (07) :949-956

[13] Improved brain and muscle mitochondrial respiration with CoQ.: An in vivo study by 31P-MR spectroscopy in patients with mitochondrial cytopathies [J].

Barbiroli, B ;

Iotti, S ;

Lodi, R .

BIOFACTORS, 1999, 9 (2-4) :253-260

[14]

Baumann K., 2017, MOL CELL BIOL, V18, P214

[15]

Berio A, 2002, PANMINERVA MED, V44, P265

[16] Clearing the outer mitochondrial membrane from harmful proteins via lipid droplets [J].

Bischof, Johannes ;

Salzmann, Manuel ;

Streubel, Maria Karolin ;

Hasek, Jiri ;

Geltinger, Florian ;

Duschl, Jutta ;

Bresgen, Nikolaus ;

Briza, Peter ;

Haskova, Danusa ;

Lejskovas, Renata ;

Sopjani, Mentor ;

Richter, Klaus ;

Rinnerthaler, Mark .

CELL DEATH DISCOVERY, 2017, 3

[17]

BLASS JP, 1991, REV NEUROL, V147, P513

[18] Staging of brain pathology related to sporadic Parkinson's disease [J].

Braak, H ;

Del Tredici, K ;

Rüb, U ;

de Vos, RAI ;

Steur, ENHJ ;

Braak, E .

NEUROBIOLOGY OF AGING, 2003, 24 (02) :197-211

[19] Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues [J].

Brambilla, Davide ;

Le Droumaguet, Benjamin ;

Nicolas, Julien ;

Hashemi, S. Hossein ;

Wu, Lin-Ping ;

Moghimi, S. Moein ;

Couvreur, Patrick ;

Andrieux, Karine .

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2011, 7 (05) :521-540

[20] The case for the development and use of "ecologically valid" measures of executive function in experimental and clinical neuropsychology [J].

Burgess, PW ;

Alderman, N ;

Forbes, C ;

Costello, A ;

Coates, LMA ;

Dawson, DR ;

Anderson, ND ;

Gilbert, SJ ;

Dumontheil, I ;

Channon, S .

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2006, 12 (02) :194-209

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