Biochemical tests for diagnosis of megaloblastic anemias

被引：0

作者：

Claudio Merlo, Hector ^{[1
]}

Monica De Paula, Silvia ^{[2
]}

机构：

[1] Soc Argentina Hematol, Hosp Gen Agudos Dr JM Ramos Mejia, Subcomis Bioquim & Biol, Lab Div Hematol, Buenos Aires, DF, Argentina

[2] Soc Argentina Hematol, Hosp Gen Agudos Dr JM Ramos Mejia, Subcomis Eritropatias, Lab Div Hematol, Buenos Aires, DF, Argentina

来源：

ACTA BIOQUIMICA CLINICA LATINOAMERICANA | 2017年 / 51卷 / 03期

关键词：

megaloblastic anemia; B-12; deficiency; folate deficiency; macrocitic anemia algorithm; laboratory tests; COBALAMIN; HOLOTRANSCOBALAMIN; VITAMIN-B-12; DEFICIENCY;

D O I：

暂无

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The aim of this article is to make a little review on Vitamin B-12 and Folate or Vitamin B-9 metabolism. These hydrosoluble vitamins have a very important role in cell metabolism. They are cofactors in metabolic reactions of methyl group transfer, essential for life maintaining. Furthermore, new laboratory tests are described, and it is evaluated which the necessary studies are to arrive at a correct diagnosis for macrocytic anemia (MA) patients, their etiology, and how many drugs frequently used in medicine originate MA. Also, the set of methodologies that can be carried out routinely in the laboratory specialized in hematology is evaluated. Finally, a diagnosis algorithm to detect MA in patients is proposed.

引用

页码：349 / 359

页数：11

共 18 条

[1]

[Anonymous], DIAGN DIV

[2] DETERMINATION OF VITAMIN-B12 (COBALAMIN) IN SERUM AND ERYTHROCYTES BY RADIOASSAY, AND OF HOLO-TRANSCOBALAMIN-II (HOLO-TC-II) AND HOLO-HAPTOCORRIN (HOLO-TC-I AND III) IN SERUM BY ADSORBING HOLO-TC-II ON MICROFINE SILICA [J].