RETRACTED: Novel drug delivery system based on doxorubicin-encapsulated magnetic nanoparticles modified with PLGA-PEG1000 copolymer (Retracted article. See vol. 50, pg. 109, 2022)

被引：47

作者：

Ebrahimi, Eommolbanin ^{[2
]}

Akbarzadeh, Abolfazl ^{[1
,2
]}

Abbasi, Elham ^{[2
]}

Khandaghi, Amir Ahmad ^{[3
]}

Abasalizadeh, Farhad ^{[2
]}

Davaran, Soodabeh ^{[1
,2
]}

机构：

[1] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz 5154853431, Iran

[2] Tabriz Univ Med Sci, Dept Med Nanotechnol, Fac Adv Med Sci, Tabriz 5154853431, Iran

[3] Tabriz Univ Med Sci, Fac Med, Tabriz 5154853431, Iran

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2016年 / 44卷 / 01期

关键词：

biomedical applications; doxorubicin; PLGA; polymeric nanoparticles; IN-VITRO EVALUATION; GENE-EXPRESSION; POLY(ETHYLENE GLYCOL); LOADED NANOPARTICLES; LIPID EMULSION; DOCETAXEL; FORMULATION; INHIBITION; PHARMACOKINETICS; MICROSPHERES;

D O I：

10.3109/21691401.2014.944646

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New drug delivery systems delivered the active molecules to the target site in a definite manner to produce the desired effects without disturbing the delicate bio-environment. The Fe3O4 magnetic nanoparticles were prepared by chemical precipitation of Fe salts in the ratio of 1:2 under alkaline and inert condition. PLGA-PEG(1000) triblock copolymer was synthesized by ring-opening polymerization. The properties of this copolymer were characterized using Fourier transform infrared spectroscopy. In addition, the resulting particles were characterized by X-ray powder diffraction, scanning electron microscopy, and vibrating sample magnetometry. The in vitro doxorubicin (DOX) release profiles were obtained by representing the percentage of DOX release. In this report, we used this new method to fabricate PEGylated PLGA particles, and examined the anticancer agent DOX.

引用

页码：290 / 297

页数：8

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