Critical knowledge gaps and research needs related to the environmental dimensions of antibiotic resistance

被引：271

作者：

Larsson, D. G. Joakim ^{[1
,2
]}

Andremont, Antoine ^{[3
,4
]}

Bengtsson-Palme, Johan ^{[1
,2
]}

Brandt, Kristian Koefoed ^{[5
]}

Husman, Ana Maria de Roda ^{[6
,7
]}

Fagerstedt, Patriq ^{[8
]}

Fick, Jerker ^{[9
]}

Flach, Carl-Fredrik ^{[1
,2
]}

Gaze, William H. ^{[10
]}

Kuroda, Makoto ^{[11
]}

Kvint, Kristian ^{[1
,2
]}

Laxminarayan, Ramanan ^{[12
]}

Manaia, Celia M. ^{[13
]}

Nielsen, Kaare Magne ^{[14
]}

Plant, Laura ^{[8
]}

Ploy, Marie-Cecile ^{[15
]}

Segovia, Carlos ^{[16
]}

Simonet, Pascal ^{[17
]}

Smalla, Kornelia ^{[18
]}

Snape, Jason ^{[19
,20
]}

Topp, Edward ^{[21
]}

van Hengel, Arjon J. ^{[22
]}

Verner-Jeffreys, David W. ^{[23
]}

Virta, Marko P. J. ^{[24
]}

Wellington, Elizabeth M. ^{[20
]}

Wernersson, Ann-Sofie ^{[25
]}

机构：

[1] Univ Gothenburg, Ctr Antibiot Resistance Res CARe, Guldhedsgatan 10A, SE-41346 Gothenburg, Sweden

[2] Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Infect Dis, Guldhedsdsgatan 10A, SE-41346 Gothenburg, Sweden

[3] INSERM, IAME, UMR 1137, Paris, France

[4] Univ Paris Diderot, Sorbonne Paris Cite, F-75018 Paris, France

[5] Univ Copenhagen, Fac Sci, Dept Plant & Environm Sci, Thorvaldsensvej 40, DK-1871 Frederiksberg, Denmark

[6] Univ Utrecht, Inst Risk Assessment Sci, POB 80175, NL-3508 TD Utrecht, Netherlands

[7] Natl Inst Publ Hlth & Environm, Ctr Infect Dis Control, POB 1, Bilthoven, Netherlands

[8] Swedish Res Council, Box 1035, SE-10138 Stockholm, Sweden

[9] Umea Univ, Dept Chem, Umea, Sweden

[10] Univ Exeter, Sch Med, European Ctr Environm & Human Hlth, Knowledge Spa,Royal Cornwall Hosp, Truro TR1 3HD, Cornwall, England

[11] Natl Inst Infect Dis, 4-7-1 Gakuen, Tokyo 2080011, Japan

[12] Ctr Dis Dynam Econ & Policy, Washington, DC USA

[13] Univ Catolica Portuguesa, CBQF, Lab Associado, Escola Super Biotecnol, Rua Arquiteto Lobao Vital,Apartado 2511, P-4202401 Porto, Portugal

[14] Oslo & Akershus Univ, Coll Appl Sci, Dept Life Sci & Hlth, N-0130 Oslo, Norway

[15] Univ Limoges, UMR 1092, INSERM, CHU Limoges, Limoges, France

[16] Inst Salud Carlos III, Unidad Func Acreditac, Inst Invest Sanitaria, Madrid, Spain

[17] Univ Lyon, Ecole Cent Lyon, Environm Microbial Genom Grp, Lab Ampere,UMR 5005,CNRS, 36 Ave Guy de Collongue, F-69134 Ecully, France

[18] Julius Kuhn Inst, Fed Res Ctr Cultivated Plants, Inst Epidemiol & Pathogen Diagnost, Messeweg 11-12, D-38104 Braunschweig, Germany

[19] AstraZeneca, Global Environm, Chester SK10 4TF, Cheshire, England

[20] Univ Warwick, Sch Life Sci, Coventry CV4 7AL, W Midlands, England

[21] Univ Western Ontario, Dept Biol, Agr & Agri Food Canada, London Res & Dev Ctr, London, ON N5V 4T3, Canada

[22] European Commiss, Directorate Hlth, Directorate Gen Res & Innovat, Brussels, Belgium

[23] Ctr Environm Fisheries & Aquaculture Sci, Cefas Weymouth Lab, Weymouth DT4 8UB, Dorset, England

[24] Univ Helsinki, Dept Microbiol, Helsinki, Finland

[25] Swedish Agcy Marine & Water Management, Box 11 930, SE-40439 Gothenburg, Sweden

来源：

ENVIRONMENT INTERNATIONAL | 2018年 / 117卷

基金：

欧盟地平线“2020”; 瑞典研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

Antimicrobial resistance; Infectious diseases; Risk assessment; Risk management; Environmental pollution; HORIZONTAL GENE-TRANSFER; ANTIMICROBIAL RESISTANCE; RISK-ASSESSMENT; ESCHERICHIA-COLI; POLICY INTERVENTIONS; PROTECTION GOALS; WASTE-WATER; BIOCIDES; BACTERIA; HUMANS;

D O I：

10.1016/j.envint.2018.04.041

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

There is growing understanding that the environment plays an important role both in the transmission of antibiotic resistant pathogens and in their evolution. Accordingly, researchers and stakeholders world-wide seek to further explore the mechanisms and drivers involved, quantify risks and identify suitable interventions. There is a clear value in establishing research needs and coordinating efforts within and across nations in order to best tackle this global challenge. At an international workshop in late September 2017, scientists from 14 countries with expertise on the environmental dimensions of antibiotic resistance gathered to define critical knowledge gaps. Four key areas were identified where research is urgently needed: 1) the relative contributions of different sources of antibiotics and antibiotic resistant bacteria into the environment; 2) the role of the environment, and particularly anthropogenic inputs, in the evolution of resistance; 3) the overall human and animal health impacts caused by exposure to environmental resistant bacteria; and 4) the efficacy and feasibility of different technological, social, economic and behavioral interventions to mitigate environmental antibiotic resistance.(1)

引用

页码：132 / 138

页数：7

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