Ligand-Free and Heterogeneous Palladium on Carbon-Catalyzed Hetero-Suzuki-Miyaura Cross-Coupling

被引：100

作者：

Kitamura, Yoshiaki ^{[1
,2
]}

Sako, Satoko ^{[1
]}

Tsutsui, Azusa ^{[1
]}

Monguchi, Yasunari ^{[1
]}

Maegawa, Tomohiro

Kitade, Yukio ^{[2
]}

Sajiki, Hironao ^{[1
]}

机构：

[1] Gifu Pharmaceut Univ, Dept Organ & Med Chem, Organ Chem Lab, Gifu 5028585, Japan

[2] Gifu Univ, Fac Engn, Dept Biomol Sci, Gifu 5011193, Japan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2010年 / 352卷 / 04期

关键词：

C-C coupling; heterocycles; heterogeneous catalysis; palladium; Suzuki-Miyaura reaction; ARYLBORONIC ACIDS; ARYL HALIDES; HETEROARYLBORONIC ACIDS; VERSATILE METHOD; POTASSIUM ARYL; PD/C; DERIVATIVES; BROMIDES; CHLORIDES; MILD;

D O I：

10.1002/adsc.200900638

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A ligand-free and heterogeneous palladium on carbon (Pd/C)-catalyzed hetero-Suzuki-Miyaura coupling reaction has been developed. The protocol enables the construction of both heterocyclic-alicyclic and heterocyclic-heterocyclic biaryl derivatives in good to excellent yields. Furthermore. Pd/C could be reused. The time-course study clarified that palladium was leached into the reaction media as the reaction proceeded and then completely deposited on the carbon support.

引用

收藏

页码：718 / 730

页数：13

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