Hydrogen Sulfide, Oxidative Stress and Periodontal Diseases: A Concise Review

被引:48
作者
Greabu, Maria [1 ]
Totan, Alexandra [1 ]
Miricescu, Daniela [1 ]
Radulescu, Radu [1 ]
Virlan, Justina [1 ]
Calenic, Bogdan [1 ]
机构
[1] Univ Med & Pharm CAROL DAVILA, Dept Biochem, Fac Med Dent, 8 Blvd EroilorSanit,Sect 5, Bucharest 050474, Romania
关键词
hydrogen sulfide; saliva; periodontitis; GINGIVAL EPITHELIAL-CELLS; TREPONEMA-DENTICOLA; CYSTEINE DESULFHYDRASE; SUPEROXIDE-DISMUTASE; ANTIOXIDANT PROFILE; METHYL MERCAPTAN; SALIVARY; LIPOPOLYSACCHARIDE; H2S; EXPRESSION;
D O I
10.3390/antiox5010003
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In the past years, biomedical research has recognized hydrogen sulfide (H2S) not only as an environmental pollutant but also, along with nitric oxide and carbon monoxide, as an important biological gastransmitter with paramount roles in health and disease. Current research focuses on several aspects of H2S biology such as the biochemical pathways that generate the compound and its functions in human pathology or drug synthesis that block or stimulate its biosynthesis. The present work addresses the knowledge we have to date on H2S production and its biological roles in the general human environment with a special focus on the oral cavity and its involvement in the initiation and development of periodontal diseases.
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页数:13
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