Galidesivir limits Rift Valley fever virus infection and disease in Syrian golden hamsters

被引：51

作者：

Westover, Jonna B. ^{[1
]}

Mathis, Amanda ^{[2
]}

Taylor, Ray ^{[2
]}

Wandersee, Luci ^{[1
]}

Bailey, Kevin W. ^{[1
]}

Sefing, Eric J. ^{[1
]}

Hickerson, Brady T. ^{[1
]}

Jung, Kie-Hoon ^{[1
]}

Sheridan, William P. ^{[2
]}

Gowen, Brian B. ^{[1
]}

机构：

[1] Utah State Univ, Dept Anim Dairy & Vet Sci, Logan, UT 84322 USA

[2] BioCryst Pharmaceut Inc, Durham, NC USA

来源：

ANTIVIRAL RESEARCH | 2018年 / 156卷

基金：

美国国家卫生研究院;

关键词：

BCX4430; Galidesivir; Rift valley fever virus; Phlebovirus; Bunyavirus; Viral hemorrhagic fever; NUCLEOSIDE ANALOG; BCX4430; MODEL; T-705;

D O I：

10.1016/j.antiviral.2018.05.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Rift Valley fever virus (RVFV) is a mosquito-borne pathogen endemic to sub-Saharan Africa and the Arabian Peninsula. There are no approved antiviral therapies or vaccines available to treat or prevent severe disease associated with RVFV infection in humans. The adenosine analog, galidesivir (BCX4430), is a broad-spectrum antiviral drug candidate with in vitro antiviral potency (EC50 of less than 50 pM) in more than 20 different viruses across eight different virus families. Here we report on the activity of galidesivir in the hamster model of peracute RVFV infection. Intramuscular and intraperitoneal treatments effectively limited systemic RVFV (strain ZH501) infection as demonstrated by significantly improved survival outcomes and the absence of infectious virus in the spleen and the majority of the serum, brain, and liver samples collected from infected animals. Our findings support the further development of galidesivir as an antiviral therapy for use in treating severe RVFV infection, and possibly other related phleboviral diseases.

引用

页码：38 / 45

页数：8

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