Multifunctional nanoplatforms for subcellular delivery of drugs in cancer therapy

被引：157

作者：

Guo, Xing ^{[1
]}

Wei, Xiao ^{[1
]}

Chen, Zi ^{[2
]}

Zhang, Xiaobin ^{[1
]}

Yang, Guang ^{[1
]}

Zhou, Shaobing ^{[1
]}

机构：

[1] Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu 610031, Sichuan, Peoples R China

[2] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA

来源：

PROGRESS IN MATERIALS SCIENCE | 2020年 / 107卷

基金：

中国国家自然科学基金;

关键词：

Nanoparticle; Targeted delivery; Cancer therapy; Organelle-targeting; Stimuli-sensitive; OVERCOMING MULTIDRUG-RESISTANCE; CELL-PENETRATING PEPTIDES; GROWTH-FACTOR RECEPTOR; LYSOSOMAL MEMBRANE PERMEABILIZATION; NUCLEAR-LOCALIZATION SEQUENCE; ESTER-MODIFIED CYCLODEXTRIN; LIPOSOME-BASED CARRIER; INTRACELLULAR DELIVERY; TAT-PEPTIDE; ANTICANCER DRUG;

D O I：

10.1016/j.pmatsci.2019.100599

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance. Targeted delivery based on nanoparticle (NP)-based drug delivery systems (NDDSs) is mainly focused on cell-membrane targeting. In this review we summarize researches on organelle-specific drug delivery with multifunctional NPs. Many effective strategies are introduced for functionalizing these NPs by altering their chemical composition or by grafting functional groups onto their surface for improving organelle-targeting ability. Only when the concentration of released drugs becomes high enough will they interact with molecular targets on specific organelles to induce tumor cell apoptosis. Organelle-specific delivery will become one of the primary goals for targeted drug delivery research.

引用

页数：24

共 315 条

[1] Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20 [J].

Abe, Y ;

Shodai, T ;

Muto, T ;

Mihara, K ;

Torii, H ;

Nishikawa, S ;

Endo, T ;

Kohda, D .

CELL, 2000, 100 (05) :551-560

[2] Monoclonal antibody therapy of cancer [J].

Adams, GP ;

Weiner, LM .

NATURE BIOTECHNOLOGY, 2005, 23 (09) :1147-1157

[3] Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers [J].

Adar, Y. ;

Stark, M. ;

Bram, E. E. ;

Nowak-Sliwinska, P. ;

van den Bergh, H. ;

Szewczyk, G. ;

Sarna, T. ;

Skladanowski, A. ;

Griffioen, A. W. ;

Assaraf, Y. G. .

CELL DEATH & DISEASE, 2012, 3 :e293-e293

[4] Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury [J].

Adlam, VJ ;

Harrison, JC ;

Porteous, CM ;

James, AM ;

Smith, RAJ ;

Murphy, MP ;

Sammut, IA .

FASEB JOURNAL, 2005, 19 (09) :1088-1095

[5] The molecular architecture of the nuclear pore complex [J].

Alber, Frank ;

Dokudovskaya, Svetlana ;

Veenhoff, Liesbeth M. ;

Zhang, Wenzhu ;

Kipper, Julia ;

Devos, Damien ;

Suprapto, Adisetyantari ;

Karni-Schmidt, Orit ;

Williams, Rosemary ;

Chait, Brian T. ;

Sali, Andrej ;

Rout, Michael P. .

NATURE, 2007, 450 (7170) :695-701

[6] Factors affecting the clearance and biodistribution of polymeric nanoparticles [J].

Alexis, Frank ;

Pridgen, Eric ;

Molnar, Linda K. ;

Farokhzad, Omid C. .

MOLECULAR PHARMACEUTICS, 2008, 5 (04) :505-515

[7] Ligand-targeted therapeutics in anticancer therapy [J].

Allen, TM .

NATURE REVIEWS CANCER, 2002, 2 (10) :750-763

[8] Stimulated endocytosis in penetratin uptake:: Effect of arginine and lysine [J].

Amand, Helene L. ;

Fant, Kristina ;

Norden, Bengt ;

Esbjorner, Elin K. .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 371 (04) :621-625

[9] Retrograde delivery of photosensitizer (TPPp-O-β-GluOH)3 selectively potentiates its photodynamic activity [J].

Amessou, Mohamed ;

Carrez, Daniele ;

Patin, Delphine ;

Sarr, Marianne ;

Grierson, David S. ;

Croisy, Alain ;

Tedesco, Antonio C. ;

Maillard, Philippe ;

Johannes, Ludger .

BIOCONJUGATE CHEMISTRY, 2008, 19 (02) :532-538

[10]

Amorim R, 2018, Mitochondrial Biology and Experimental Therapeutics, P333

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