Regulatory T cells in vitiligo: Implications for pathogenesis and therapeutics

被引：97

作者：

Dwivedi, Mitesh ^{[1
,3
]}

Kemp, E. Helen ^{[2
]}

Laddha, Naresh C. ^{[3
]}

Mansuri, Mohmmad Shoab ^{[3
]}

Weetman, Anthony P. ^{[2
]}

Begum, Rasheedunnisa ^{[3
]}

机构：

[1] Uka Tarsadia Univ, CG Bhakta Inst Biotechnol, Surat 394350, Gujarat, India

[2] Univ Sheffield, Dept Human Metab, Sheffield S10 2RX, S Yorkshire, England

[3] Maharaja Sayajirao Univ Baroda, Dept Biochem, Vadodara 390002, Gujarat, India

来源：

AUTOIMMUNITY REVIEWS | 2015年 / 14卷 / 01期

关键词：

Autoimmunity; CD8(+) T cells; Melanocyte; Pigmentation; Regulatory T cells; Vitiligo; GROWTH-FACTOR-BETA; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; TGF-BETA; DENDRITIC CELLS; SOLUBLE CTLA-4; CUTTING EDGE; EX-VIVO; B-CELLS; CD4(+); FOXP3;

D O I：

10.1016/j.autrev.2014.10.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vitiligo is a hypomelanotic autoimmune skin disease arising from a breakdown in immunological self-tolerance, which leads to aberrant immune responses against melanocytes. Regulatory T cells (Tregs) are crucial to the development of self-tolerance and so are major foci in the study of autoimmune pathogenesis of vitiligo. This review will summarise recent findings concerning the role of Tregs in the pathogenesis of vitiligo. In addition, as antigen-specific Tregs are a potential route for the reinstatement of immune tolerance, new strategies that expand or induce de novo generation of Tregs and which are currently being investigated as therapies for other autoimmune diseases, will be discussed. These approaches will highlight the opportunities for Treg cell-based therapeutics in vitiligo. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：49 / 56

页数：8

共 110 条

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