Synthesis and Biological Activity of 6-(Substituted)-3-(3,4,5-trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole

被引：0

作者：

Du, Haitang ^{[1
,2
]}

Du, Haijun ^{[3
]}

机构：

[1] Tianjin Univ, Dept Chem, Coll Sci, Tianjin 300072, Peoples R China

[2] Guiyang Coll, Dept Chem, Guiyang 550003, Peoples R China

[3] Guizhou Univ Nationalites, Sch Chem & Environm Sci, Guiyang 550025, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 30卷 / 01期

关键词：

4-amino triazole; triazolo thiadiazole; fungicidal activity; BRIDGEHEAD NITROGEN ATOM; PHARMACOLOGICAL-ACTIVITIES; ANTIMICROBIAL ACTIVITIES; ANTI-HIV; DERIVATIVES; THIADIAZOLE; SYSTEMS;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Eleven 6-(substituted)-3-(3,4,5-trimethoxyphenyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives 5a similar to 5k were synthesized by cyclization of 4-amino-5-(3,4,5-trimethoxybenzyl)-3-mercapto-1,2,4-triazole (4) with various substituted aromatic acids through a single step reaction. IR, H-1 NMR, MS techniques and elemental analysis confirmed the structures of the newly synthesized compounds. Preliminary bioassays indicated that some compounds showed fungicidal activity.

引用

页码：137 / 141

页数：5

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